just an FYI for you,but after my last knee surgery,i started having symptoms of a possible infection(it was not what it turned out to be tho)but they placed me on cipro for i think it was like ten days or so?but i was already taking my normal oxycontin like usual and also was taking extra percocet for the surgical pain too and never ever had any problems at all.when the PA at my orthos went to place me on the cipro,she actually had to go thru her little 'book' of the best possible type of anti B for my situation(i have very bad reactions to most oral anti Bs),so i KNOW without a doubt that she looked this up before she called in the Rx.i would be pretty safe in assuming that if everything is normal and you have no underlying medical issues going on,this combo would be okay.i know my PA did check this all out with me over the phone.i was actually kind of suprised that i didn;t have any real type of normal stomach burning like i do with other anti Bs i have tried.it worked well.but you can always call your pharmacy just to be sure for your particular medical history.hope all goes well for you,Marcia