maxjasper
10-06-2003, 02:17 PM
What have we learned from ALLHAT?
• Low-dose thiazide diuretics are a cornerstone of
antihypertensive therapy and preferred first-line agents
due to effectiveness, safety, tolerability and low cost.
Results consistent across age, gender & diabetes subgroups.
• Most patients will require combination therapy with
more than one agent to achieve blood pressure control
(63% of patients required ≥2 drugs for control at 5 years;
this is encouraging since the rate of blood pressure control in
treated Canadian patients is about 13% 4).
• α-blockers (e.g. doxazosin) are not first-line agents for
hypertension based on unfavorable outcomes (↑HF). If
used, consider additional antihypertensive agent.
• Concerns dispelled regarding CCBs (MI, cancer, bleeding)
CVD Risk Assessment Tables (http://www.rxfiles.ca/acrobat/HTN-Update-2003-Final.pdf)
• Low-dose thiazide diuretics are a cornerstone of
antihypertensive therapy and preferred first-line agents
due to effectiveness, safety, tolerability and low cost.
Results consistent across age, gender & diabetes subgroups.
• Most patients will require combination therapy with
more than one agent to achieve blood pressure control
(63% of patients required ≥2 drugs for control at 5 years;
this is encouraging since the rate of blood pressure control in
treated Canadian patients is about 13% 4).
• α-blockers (e.g. doxazosin) are not first-line agents for
hypertension based on unfavorable outcomes (↑HF). If
used, consider additional antihypertensive agent.
• Concerns dispelled regarding CCBs (MI, cancer, bleeding)
CVD Risk Assessment Tables (http://www.rxfiles.ca/acrobat/HTN-Update-2003-Final.pdf)