I know the positive, then negative feeling. My ANA went up stayed up and suddenly was normal. I have the rash, fatigue, terrible joint pain, mouth sores, lots of fun goodies. Two reasons your ANA may have gone down to normal. (1) medication, sometimes with medication the ANA does return to normal but the symptoms don't disappear. (2) You could be going into a remission of whatever caused it to rise in the first place. Ok, I have more than two reasons (3) you may have thyroid or other problems that would cause the ANA to go up and if they were treated that would correct count. I thought of the last one because I had a doc tell me that could be the reason my ANA count went down, when my thyroid was being treated. Although the endocrinologist didn't seem too interested in it. As I was being treated by the rhuematologist and he was checking the ANA count regularly it finally went down to normal. He suggested taking the right meds may have helped it but sometimes there isn't alway a reason. I thought of another reason (4) it could also depend on the lab and the kind of testing ordered by the doc. Some are more specific than others.

I hate the non specific nature of fibro and all this other 'junk' but it is what it is. I still search for answers and stay on top of my medical care but I also have learned not to push but to gently prod my doc for more info and answers.

Hope this helps.
Glojer