AuRx, Inc., Announces Publication Of The Successful Results Of The Clinical Evaluation Of Its Therapeutic Vaccine For Genital Herpes


BALTIMORE, Oct. 11 /PRNewswire/ -- The Mexican clinical team evaluating the AuRx therapeutic vaccine for genital herpes has published the initial results of a safety evaluation for the lowest dose in a Phase I/II trial for treatment of genital herpes in the October issue of Cutis. There were no treatment related adverse events in the trial and the side effects were similar to that of a sugar pill. Dr. Gerardo Casanova, the lead investigator said, "Of most importance, is that we now potentially have available a therapeutic vaccine that will avoid many complications for the patients, and in particular the serious perinatal risks."

In the first finding of its kind in the history of the treatment of genital herpes, the AuRx therapeutic vaccine reduced the number of episodes three fold (P less than .001) versus the previous year. In addition, recurrent HSV-2 episodes were completely prevented in 37.5% of vaccinated patients as opposed to the patients given placebo, all of whom had episodes during the trial period. These patients had previously had 5-24 outbreaks per year. In statistically significant results, vaccinated patients had 50% fewer recurrences and 45% fewer illness days (P=.028) than the placebo. A reduced severity of the herpetic episodes in vaccinated patients was observed as lesions were 4.8 times more prevalent in untreated patients, pain was 2.9 times more prevalent in untreated patients and itching was 3.7 times more prevalent in untreated patients.

The trial continues by tracking for clinical outbreaks over a two-year period. AuRx plans to run additional studies in larger groups with higher dose levels and additional vaccinations. In guinea pigs which were first infected with genital herpes and then given the same dose schedule used in the human clinical trial, 70% of the animals had no recurrences. Higher doses and a different dose schedule in animals resulted in over 90% prevention of recurrences.

Over 50 million Americans are infected with genital herpes. The incidence of genital herpes is rapidly increasing world wide and is projected to affect 39% of women and 49% of men aged 15 to 39 in the US by 2025. At present there is no convenient method to prevent recurrences of these painful lesions which are often transmitted to sexual partners. Treatment of herpes with currently available drugs only slightly reduces the time the patient has lesions. It also requires reliably taking medication on a daily basis since failure to do so usually results in an episode. Over the last three decades, pharmaceutical companies have failed in their attempts to develop a herpes vaccine as none have achieved statistical significance in trials nor have any shown therapeutic effects.

AuRx, Inc., is a privately held company developing methods for treatment of recurrent and long-lasting viral disease.

I also posted this information on other message boards for people with herpes after I talked to Gary Carlton who is the President of AuRx. God bless you all.

Not sure if they would work for HSV-1, but I am assuming so or at the very worse it would only take them some slight adjustments to the existing vaccine.

OK, I just talked to Gary Carlton at AuRx and he was a really nice gentlemen and very happy about the results. He stated that the vaccine really works and out of all the people that were tested with the vaccine only four people had any vesicles / lesions reappear, which were very mild compared to the patients continuos multiple OB's prior to vaccination. This success was with the lowest/minimal dose, which was very encouraging. He went on to state that what they are basically doing now is:
1. Following patients who have been vaccinated to see how long the vaccine works or stays in an individuals body.
-AND-
2. Testing individuals with a different dosage (I am assuming higher dosage) to see if recurrences ever happen again.

He stated that the vaccine was sort of like a Tetanus shot were an individual might have to get it once every 5 or 10 years. The Mexican Ministry of Health wants AuRx to follow people who have been vaccinated for two years and follow their progress.

As I mentioned in my previous post I thought/believed the vaccine would be available in Mexico or some other country way before it would be available here in the US and Mr. Carlton confirmed my belief. He stated that the vaccine should be available in Mexico and South America probably within a couple of years and then Europe, and after that the United States. He stated that it should be available in the US in 4 or 5 years. This was his "guesstimate"

As he stated so aptly to me that this is the reason for them holding there clinical trials in Mexico because the process is much shorter than holding clinical trials in the US.

He stated that the best thing we can do and this is IMPORTANT.. Is to call our local newspapers, magazines, etc. and tell them about the success of the clinical trial so they can get the word out via their publications or whatever. This in turn will interest investors and the rest is history. Once this happens it will all start to roll down hill and the vaccine will be available here in the US!! Like I've stated before.. Once these trials are proven I will not hesitate to go to Mexico. I am not going to wait for the FDA to drag their feet, but this will not stop me from trying to help it getting approved here quicker in the US, since I would like to see as many people helped out as possible with this infection.

With all this being said..... I hope all of us call our local newspapers and do whatever we can do to get the word out.

This is just my personal opinion, but I have a feeling that if AuRx doesn't partner up with a major pharm company the FDA will either

1. Take forever to approve the use of this vaccine

-OR-

2. Not approve it at all no matter how successful it is!! The reason for this is because they are so intertwined with the big pharm companies. They will loose billions of dollars on suppressive therapies and therefore make up some story that the efficacy was not proved here in the US therefore they will not approve it. REMEMBER PEOPLE the bottom line is money.. This is very sad to say, but its the truth.

May God bless all of you and may God bless AuRx and this vaccine. Please contact your local papers and get the word out.

This is amazing!! I posted this great news and nobody has replied or seems to care!! WOW!! I guess I'm just shocked! OH WELL, God bless you all!!

Originally posted by Hwklatino:
This is amazing!! I posted this great news and nobody has replied or seems to care!! WOW!! I guess I'm just shocked! OH WELL, God bless you all!!

First of all, there aren't exactly hoards of people who frequent this board. Second, I'm sceptical because I hadn't heard of a study of this nature being done, and have sent a request to a medical site to check out your claim. Third, what you have written comes across like SPAM which I normally don't reply to, no matter where I find it.

TheOneInFour

1in4,

First, I know a lot of people probably don't visit this site, but I thought I would at least get a response or something because I know a lot of people including myself suffer from this infection and this was the best news to date unless someone knows of another medication with the same results.

Second, I can understand why you might be skeptical because you haven't heard of this study/clinical trial. I am glad you sent a request to a medical site you trust to check out my claim about the AuRx clinical trials. You will see that I'm telling the truth!

Third, Don't judge a book by its cover!! I have no affiliation whatsoever with AuRx! I was just excited about the news of a therapuetic vaccine. I'm sorry it came across like SPAM, but coming across like SPAM is the exact opposite of what I attended to do. All I did was post the LEGITIMATE press release from AuRx. My second post after I posted the press release was to inform people of what Gary Carlton told me after talking to him. Gary Carlton is the President of AuRx.

One of the head researchers (And I am assuming this is where the company AuRx gets its name from)is Dr. Laure Aurelian. She is Professor of Pharmacology and Experimental Therapeutics and Microbiology and Immunology at the University of Maryland. She received her Ph.D from John Hopkins University. She deals with Molecular biology and immunology of herpesvirus infections; oncogenes and vaccine development; antisense gene regulation. If you don't believe me you can look it up yourself or better yet wait for your reliable medical site you trust to confirm what I am saying!

Like I stated before. I was very excited about the news and just wanted to inform people.

Nat

I was hopeful when I read this, but skeptical too, especially when you mentioned Mexico. If I had a dollar for everyone who went to Mexico to receive a "cure", I could afford to go to Mexico and get cured LOL. I have heard about the Antisense technology and it sounded more promising than just reducing the frequency and severity of OBs (those who know me know that bugs the hell out of me), but of course I won't complain.

I think we are very cautious about getting hopes up. Some people that come here have had HSV for many years and have heard rumors and promises all too often, only to be let down. This is hard to deal with, emotionally, and the defence to it is not to let it happen. I think this is why the response of the board seems cold. Myself, I am optimistic, but pessimistic about the FDA if this AuRx therapy will make us less dependant on Glaxo Smithkline's *****clovir monopoly. If it's any good they probably won't approve it. I guess we'll just have to wait and see, it's still years away - much too soon to do any celebrating.

NonExist

Hello NonExist,

I feel the same exact way you do!! About the FDA and the Glaxo Smithkline's *****clovir monopoly that is... I'm not sure if you read my second post NonExist (because it was quit long..lolol), but at the end of my second post I gave my personal opinion of what I thought would happen with the AuRx vaccine after this next successful clinical trial and also if they didn't partner-up with a big pharmaceutical company!

One of two things will happen if they don't partner-up with a big pharmaceutical company:

1. The FDA will take forever to approve the use of this vaccine
-OR-
2. The FDA will not approve it at all no matter how successful it is!! The reason for this is because they are so intertwined with the big pharm companies. They will loose billions of dollars on suppressive therapies and therefore make up some story that the efficacy was not proved here in the US and therefore they will not approve it. REMEMBER PEOPLE the bottom line is money.. This is very sad to say, but its the truth.
The efficacy of this vaccine is already proven with the success of this clinical trial. What they are basically doing now is what I would like to call "house-cleaning" or tying up the loose ends! From what I understand the next phase of the clinical trial or what they are basically doing is:
1. Following patients who have been vaccinated with the lowest minimal dose to see how long the vaccine works/stays in an individuals body.
-AND-
2. Testing individuals with a different dosage (I am assuming higher dosage) to see if recurrences ever happen again at all.
This is definitely not a stupid Dr. Suarez hoax or anything even close to that!! The only reason the clinical trial is being held in Mexico is because the clinical trial can be done in a 1/3 of the time it would take to do it here in the US and the other reason is because it is much cheaper to hold a clinical trial down in Mexico. Like I stated before the lead researcher for this vaccine is Dr. Laure Aurelian. She is Professor of Pharmacology and Experimental Therapeutics and Microbiology and Immunology at the University of Maryland.
Sorry for rambling NonExist (I tend to do that..lololol) but like you, I feel the vaccine is years away in the US. The only reason I am semi-celebrating is the fact that it will be available in Mexico, South America, and Europe way before it will be available here. Believe me I would not hesitate on planning a vacation to Cancun, Brazil, London, etc.. and while there being able to get this therapeutic vaccine!!
Believe me when I say this... If AuRx doesn't partner-up with Glaxo Smithline or another big pharm company they will do everything in their power to disregard this vaccine as not being efficient, safe, etc., and thus not approving it via the FDA. People need to wake up and smell the coffee about the FDA and big pharm companies! Come to think of it.. Even if AuRx tried to partner up with the big pharm companies/FDA they probably wouldn't approve this vaccine or take their sweet 'ole' time because they would loose billions on suppressive therapy medication like Valtrex, Zorvaix, etc.
People please keep an open mind. It might not be available in the US for sometime because of the politics behind the FDA, but it will be available. God bless to all!!

Hwklatino is telling the truth!!! I contracted h last year and when I was doing my research on it, I came across an article on theracine. The article was written shortly right when the clinical trial was starting. I spoke to Dr Aurelian (the angel that created the vaccine) and with Dr Carlton. Anyway, I had been waiting on the results of that trial ever since, and now that they're finally here, I've been sharing it with everyone I know!! If you want more "proof" that theracine is the real deal, then you can go to Aurx, Inc web site. It's www.aurx.com. (http://www.aurx.com.) You can also go to www.biospace.com, (http://www.biospace.com,) www.google.com, (http://www.google.com,) www.findarticles.com (http://www.findarticles.com) and do a search for theracine. As a matter of fact, here is the link for one of the first papers about theracine:
http://www.findarticles.com/cf_0/m0UMR/9_21/65714168/p1/article.jhtml?term=theracine

I understand why people may be skeptical (I think I just butchered that word!!). When I was first diagnosed, I was optmistic that a cure would be found. But after reading different articles, their negativity along with the failures of other "possible cures", I became discouraged and gave up hope. Even after talking to Dr Carlton, I was worried that this would be just another failure, but I was wrong (thank God!!!). Part of the reason that theracine works while all others failed, is because of the way it's made. I won't go into details (that's what the article is for), but theracine stimulates the body's own immune system to fight the virus, instead of relying on drugs.

Like Hwklation, I'm concerned that the FDA won't aprrove the vaccine even if it is clearly better than current drugs. Hopefully, they will realize that there is more money to be made from a cure than there is to be made from a "treatment" because everyone will pay for a cure, but not everyone takes the drugs. We must spread the word and stay strong. I know it's hard because I'm still trying to absorb it myself. I have prayed that the theracine will work ever since I found out about it, and now that day has finally come!!!

Originally posted by sum1likeme:
We must spread the word and stay strong.

You know, you still come across sounding like SPAM, Hwklatino. If you're going to double post like that, you should at least try to disguise your writing style.

And WHY should we "spread the word"? If this is as effective as you say, the word will get around without you flogging it. You've made your point.

TheOneInFour

No, this is not Hwklatino. I said to spread the word because apparently not too many people know about the clincal trials. You didn't.

You said something along the lines that if the product works, then the word will spread regardless. Well, that's not necessarily true. Have you heard of resiquimod which is another treatment for h?? Besides people that already have h and some researchers, who else would care? There are countless clinical trials going on, with positive results, that we know nothing about. And probably wouldn't care to know about until it affected one of us. As for the theracine, it's not like the results were broadcasted all over the news!!!

I don't know what to think here, but we have to strive to be open to anything. I have seen the trial results on AuRx's website, and on some other medical news sites. Time will tell if this is legit or not, I think it is - but you guys do seem like shareholders or something, LOL. How do you get to talk to so many high profile execs, anyway? However, I have my oxygen "movement" that I feel very strongly about and come across as fanatical sometimes due to my optimism about it. I will try the AuRx if it doesn't cost too much.

NonExist

Originally posted by sum1likeme:
No, this is not Hwklatino. I said to spread the word because apparently not too many people know about the clincal trials. You didn't.

...until Hwklatino/you (sorry if I'm still sceptical) posted two very lengthy and detailed posts about it...making your pep rally redundant. I'm not suggesting we don't post about news. I'm saying this one has been overdone...like Spam. You've made your point.

Have you heard of resiquimod which is another treatment for h??

Yes, and from this board. If you'd like to do a search you'll find several discussions about it.

If the AuRx vaccine is as good as it sounds, it will be heavily marketed. No one is going to put that much time, energy and money into developing a medical treatment without plans to do a major marketing campaign to sell the stuff. It's the only way they can recoup their investment. Believe me, we'll hear about it!

TheOneInFour

[This message has been edited by TheOneInFour (edited 10-22-2002).]

Well, I've sent the articles to my local newpapers and tv stations (I still have 3 more to send it to) so hopefully they will share it with the people. I searched all of the papers just to see if they had already reported on the clinical trial, but they didn't. I'm not surprised though. Since I live in a major city, hopefully larger companies will see/hear about the trials and take interest if they haven't already.

I don't mean to come off as SPAM, but I am just really excited!!! Like I said in a previous post, I've been interested in the results of this trial since I first read about it last year. I don't know about you, but when I was diagnosed with h last year, I was devastated. I couldn't and still can't accept having something like this for the rest of my life. So, I've always been hoping and praying that a cure or something would be found. By the way, it is surprisngly easy to get in touch with people these days thanks to the net!! Dr. Aurlian's (sp?) name and exact title were mentioned in the first artilce about theracine, along with the University's name that she works at. So I did a search for that school, and was able to get her contact info. She gave me Dr Carlton's telephone number since he was in charge of the trial. Also, if you go to Aurx's web site, they have a link so that you may e-mail them.

I know this may seem to be too good to be true, and it's understandable that you're hesitant. If I hadn't known about the clinical trials beforehand, I'm sure I would feel the same way. Hell, even after reading the results, I was excited but still a little skeptical. But it has sunk in that this is really happening. But, it's better to be safe than sorry. I was disappointed when another company's clinical trail failed. I'm not sure exactly but I think the product was called DISC-HSV or something like that by Galxo-Kline and Cantab? Anyway, after getting let down I was afraid the same thing would happen with the theracine. But it didn't. One of the few things that helped me to keep hope alive, just a little bit, was knowing that there wasn't always a vaccine or cure for diseases such as polio, syphlis, mumps, chylamidia, etc. but there is now. So, that makes it easier for me to believe that a vaccine and/or cure will be found for other diseases such as herpes, cancer, warts, etc.


Oh and one more thing, my posts are long because I'm a chatterbox, especially when it comes to something that I'm really interested in!! And no, I'm not offiliated with Aurx or theracine in any type of way. I wish I was cause then I could retire in a few years when theracine takes off!

1in4,

This is Hwklatino and not sum1likeme!! I'm glad someone else is as excited about the news of the results of the AuRx vaccine as I am!! My post were long because I was excited about the results and wanted to make people aware of it.

Let me see if I can change my writing style this time for you... YOU HAVE BALLS talking about SPAM!!

Why don't you call Dr. Aurelian at the University of Maryland and talk to her yourself, unless of course you don't believe the University of Maryland exists!!!

I have checked numerous web sites to see if anyone posted news of this clinical trial... And guess what? There wasn't anything on any of those sites, so I posted the info there also!! I am excited about the news and you won't dampen my spirits with your negative attitude! If its not successful then its not successful , but for now it gives me hope and that's all a person can ask for.

You stated:
-------------------------------------------------------
If the AuRx vaccine is as good as it sounds, it will be heavily marketed. No one is going to put that much time, energy and money into developing a medical treatment without plans to do a major marketing campaign to sell the stuff. It's the only way they can recoup their investment. Believe me, we'll hear about it!
-------------------------------------------------------

You obviously don't get it!!! Things are not as simple as you just stated! AuRx is a small corporation, if you would like to call it that. AuRx consists of a few incredibly gifted researchers.

If the AuRx vaccine is as successful as it seems to be, the FDA will do everything to hold it down! Why you might ask? Because the big pharm companies run the FDA and thus the FDA/pharm companies will loose billions of dollars on suppressive therapies such as Valtrex!!

You need to wake up and smell the coffee 4 real!!! Here's a link on an article written on September 30, 2002 on just how much Glaxo would loose if a vaccine like Theracine would be available. The article is titled: Sales of Glaxo Herpes Drug Seen Soaring -http://www.twincities.com/mld/twincities/4183660.htm

If Theracine is as successful as it seems it will be then you can go ahead and swallow down Valtrex everyday for the rest of your life for all I care (you seem like that type of person anyway with your negative attitude), but I will opt for the Theracine!!

I hope my writing style is different enough for you this time!!. I guess being polite and relaying info I thought was useful is not your cup of tea, so I changed my style just for you!!

Here's more proof for you non-believers!


For Immediate Release November 11, 2002

AuRx, Inc. - Baltimore

Dr. Joseph Burnett,will discuss the recently completed one year follow-up data for the Phase I/II clinical trial of the AuRx therapeutic vaccine for prevention of genital herpes at the Eugene Bereston Lecture on Nov 19, 2002.

The results of the low dose arm of the trial were recently published in Cutis, a dermatological journal. In that study, the publication reported the recurrence rate was reduced 84% from the previous year (P<.001) and 37.5% of the treated patients had no recurrent episodes (complete prevention of all symptoms) (P=.06). The study achieved statistical significance in all the secondary endpoints, including reduction of illness days and reduction of recurrences.

The severity (pain, itching, lesions, vesicle formation, dysuria) and duration of attacks in those patients having episodes was considerably reduced. Further patient follow-up and scientific studies of the patients in this trial are being envisaged to examine its disease-modifying effects over the long-term. Additional new studies are being planned to confirm these promising findings.

In the high dose arm, two shots of 10^6 pfu were given as opposed to three shots of 105 pfu which were given in the low dose arm.

Genital herpes affects over 60 million Americans with 910,000 women and 730,000 men contracting the disease each year. This disease normally results in 6 outbreaks per year but in severe cases more episodes may result. Increasing resistance to the nucleoside analogs currently used to treat genital herpes is being reported. The psychosocial consequences of genital herpes is quite significant as 57% of those infected indicate that herpes interfered with their sexual relationships, 50% felt it was difficult to live with genital herpes and 37% felt that herpes ruined their lives.

The Eugene Sydney Bereston Memorial Lecture is given annually by an invitee of the Maryland Dermatologic Society and is dedicated to an outstanding scientist and physician who studied cutaneous diseases for many years. The lecture by Dr. Burnett will be given on November 19, 2002 at the University of Maryland School of Social Work auditorium at 525 West Redwood Street at 1:15 PM.

or Additional Information Contact:
Gary J. Calton, President AuRx, Inc.
500 J McCormick Drive
Glen Burnie, MD 21061
410.590.7610

Some more good results of the AuRx vaccine in case anybody in interested. I posted their latest press release below! God Bless...

For Immediate Release November 19, 2002
AuRx, Inc. - Baltimore

Dr. Joseph Burnett discussed the recently completed one year follow-up data for the Phase I/II clinical trial of the AuRx therapeutic vaccine for treatment of genital herpes at the Eugene Bereston Lecture today.

The AuRx therapeutic vaccine completely prevented all signs and symptoms of recurrent genital herpes in 43.5% of the patients for 12 to 15 months (entire length of follow-up to date). One year data on the high dose arm, where only two shots rather than the three given in the low dose arm, was significant relative to the entire study placebo at P=.025. The therapeutic vaccine was equally effective in both men and women. The number of herpetic episodes in the treated group was reduced 71% from the previous year (P<.001).

The results of the low dose arm of the trial were recently published in Cutis, a dermatological journal. In that study, the publication reported the recurrence rate for episodes of genital herpes was reduced 84% from the previous year (P<.001) and 37.5% of the treated patients had no recurrent episodes (complete prevention of all symptoms) (P=.06). The study achieved statistical significance in all the secondary endpoints, including reduction of illness days and reduction of recurrences. The severity (pain, itching, lesions, vesicle formation, dysuria) and duration of attacks in those patients having episodes was also considerably reduced.

Further patient follow-up and scientific studies of the patients in this trial are envisaged to examine its disease-modifying effects over the long-term. Additional new studies are being planned to confirm these promising findings.

Genital herpes affects over 60 million Americans with 910,000 women and 730,000 men contracting the disease each year. This disease normally results in 6 outbreaks per year but in severe cases more episodes may result. Increasing resistance to the nucleoside analogs currently used to treat genital herpes is being reported. The psychosocial consequences of genital herpes is quite significant as 57% of those infected indicate that herpes interfered with their sexual relationships, 50% felt it was difficult to live with genital herpes and 37% felt that herpes ruined their lives.

The Eugene Sydney Bereston Memorial Lecture is given annually by an invitee of the Maryland Dermatologic Society and is dedicated to an outstanding scientist and physician who studied cutaneous diseases for many years.

or Additional Information Contact:
Gary J. Calton, President AuRx, Inc.
500 J McCormick Drive
Glen Burnie, MD 21061
410.590.7610

Here's an e-mail I received from Dr. Calton about some questions I had:

Q. How can US citizens with Herpes support AuRx in bringing their work to
the US?A. AuRx must raise funds for commercialization. Publicity of the
outstanding results and the hope it offers the 60 million sufferers of Herpes in the US are the surest way to attract funding. Contact your local
newspapers, radio and TV stations with our press releases and your comments. Your comments are what will cause the media to turn its attention to this
treatment. The quickest way to make the therapeutic vaccine available is to continue the work in Mexico. With proper funding we believe that AuRx could obtain
approval for sale in 2004. The data gained in Mexico should allow us to move more quickly in our trials in the US as we would know the best dosage and markers for US trials.

Q. When will the treatment be available abroad, and how might one participate in future trials?
A. Our progress in funding and setting up clinical trials will be announced on our web site. Some sufferers keep contact with this site and spread the
news to other sites. Please help by spreading the word.

Q. For those that haven't had any recurrences, is it still possible to have asymptomatic shedding with this product?
A. Additional studies are needed to answer this question.

Q. In an earlier paper, I believe it was stated that the virus was undetected in some of the guinea pigs treated. Has this also been the case in any of the humans?
A. It is not possible to run the same experiments. In the guinea pig studies, we took out the ganglia near the injection site, ground them up and looked virus particles.

Q. Since this treatment has the potential to eliminate outbreaks, can it be considered a cure---excluding the facts that the virus will probably still
remain in the ganglia and that "booster shots" may be needed?
A. We believe that this is "essentially" a cure. One of the studies currently underway is the determination of how long this "cure" will last. The one year results will be published Nov. 19 (see press release on website).

Q. Someone posted on a health board that people should contact their local tv stations, newspapers, etc and tell them about the success of Theracine. I
have contacted all the tv stations and newspapers in my area and I would like to know if there is anything else I can do to help?
A. If they haven't carried an article on the disease and its treatment, contact them again and ask why not.

Q. Can the same ideology used to develop Theracine be used to develop a similar product for genital warts?
A. Yes. In addition, we believe that it can also be used for HIV and a number of other long lasting or recurrent viral diseases.

When will people be able to get this drug?

is it available in Canada?

isn't there a vaccine almost ready now by glaxosmithkline for herpies? A couple weeks ago, a vaccine by the same company was announced for HPV(genital warts)- (of course they sold it in the media as a vaccine for cervical cancer to it it more widespread popular appeal), and in the same media release, they announced that a vaccine for herpies was almost ready. This was in Canada. Anyone know bout this?

Is it safe to say that this is another form of suppresive therapy? This does not seem to be a cure unless if I read this improperly. I need clarification. Is this a cure? No more antibodies? Or is this just to suppress, reduces outbreaks? Your information would be appreciated. Thanks.

I must say I'm with Arti -- this seems not to be a vaccine for those who do not have it (which was what I thought a vaccine essentially was) but instead sounds more like a drug to lessen symptoms (which of course isn't a bad thing if it does a better job than daily medication.) That is how I am reading these PRs. It sounds like a one time dose with possible follow-up booster shots to result in supressing symptoms.

Can anyone clarify this??

(Of couse if it could also stop transmission we'd all burst into song or something, but I'm sure trials to find out that would take additional years.)


[This message has been edited by feeling_lost (edited 01-12-2003).]

A vaccine, according to the On-line Medical Dictionary, can be used to prevent an illness or to improve the person's condition who already has it (i.e., treatment).

From what I can understand, the whole concept of a "cure" is very elusive when it comes to herpes, for a variety of reasons. We just don't understand the reactivation process enough to know whether the virus is truly rendered inactive in all possible instances.

And while the virus resides in the spinal nerve ganglia while dormant, it also leves its DNA in the cells infected during an OB, and the roles each plays in reactivation isn't fully understood at this point. So there are a number of areas that could and would need to be addressed when assessing a "cure."

Even a cold virus leaves antibodies forever in our system, so by what yardstick can we measure the absence of virus? The herpes antibodies will always be with us. And we can't even detect with 100% certainty when the virus is active, since swab cultures are not always reliable.

From the AuRx information, it would seem that their vaccine *might* be able to reduce symptoms to one extent or another. How reliable this is and what range of effectiveness there is, has yet to be fully determined. Let's keep our fingers crossed though. http://www.healthboards.com/ubb/smile.gif

TheOneInFour