Hi there! I am on prilosec too. I have been having problems for almost a month. It took 3 days for me to even feel a thing. And then it was like it was gone. I still have flare ups, but you should feel relief by 3 to 5 days or so. If you have gone beyond that and not notice much of a difference I would definately try something else. Thats just my opinion. Good luck! Hang in there! I know how it feels.:angel: