I am on my 3rd week of lipitor. I have experienced muscle cramps, esp in calves, and hamstrings. The hamstrings feel tight all the time. I contacted my dr. He said to give it few more days. He wants me to draw blood next week. Well, I think I am going to stop the meds tonight. I am tired of the pain. Funny how we feel great with our elevated cholesterol, then feel like crap on the meds! Leave us alone! I don't know what the next step will be, but hey, who cares? I may ask him to try Zetia. I tired of all this blood drawing. I think the drs see me as a way to pay for their lake house. You guys have a super day. Remeber life is Really Good!