... my first major anxiety attack was in my early 20s and was spurred by an adverse reaction to Nytol or Nyquil, taken for some cold symptoms I was having. As best as I remember I took the Nyquil, fell asleep and woke up in a complete panic. Although it was the middle of the night, I had to go to a friend's place. It's hard to remember, but I was in a bad state for a few weeks - disaster.