Hi, I have been reading this board for quite awhile now, and i have the same pronlem as you.I was beginning to think that i was the only one with this problem.Do you have ms?. I have been going through tests, and they havn't decided which i have md or ms. There leaning towards md. These knots are very painful. I am a new grandmom and she weighs only 4 lbs and where her head lays i get this large knot. I always have these large lumps on my thighs also there all the time.My arms and thighs are the worst. If i sit to long i get knots in my back and then i can't move . Does this sound the smae, if so you no the pain it entails. In fact i go to the drs today, and i don't know whats up as far as tests go this time, but as time goes i'm getting weaker all the time, my upper arms knots quite often and theres alot of pain that goes with this. I hope this helps making you feel that your not alone, what do these systoms sound like to you Hope