Bone density loss, bone abnormalities, calcification of ligaments and tendons,hyperostosis,premature epiphyseal closure,arthritis,tendonitis, other bone abnormalities---update(May-2000) pharmaceutical insert on the acne prescription medication, Accutane.


Irreversible Skelatal Changes
AM J Phys Med Rehab, Vol. 78, Page 571-6

Excerpt---
"Irreversible changes have been described in patients treated with Accutane. Skelatal lesions, rhumatologic consequences, enthesopathy...
Physicians who are treating patients with a history of Accutane use should be suspicious of underlying enthesopathies as the etilogy behind pain of muscoskelatal origin."