bjg
04-07-2002, 05:09 PM
CAN ANYONE TELLL ME GOOD OR BAD WHAT THEIR EXPERIENCE HAS BEEN WITH EVISTA FOR BONE LOSS..I KNOW THAT ONE OF THE POSSIBLE SIDE EFFECTS IS BLOOD CLOTS..DOES ANYONE KNOW IF THERE IS A BLOOD TEST TO DETERMINE ONES PROPENSITY FOR CLOTS AND WHAT THE NAME OF THE TEST IS...
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jir
04-20-2002, 06:27 PM
I've been taking Evista for a year and it's great, except that now my esophagus is getting affected. It seems harder to swallow, I mean I feel my esophagus, and my breathing is a little harder. It's odd because I'm a professional flutist. I'm not sedentary any more, but I'm 49 and very small, Cauc. and 4'11" tall.
My health is still excellent otherwise; I've always had very low cholesterol, so it prob. also depends on your body type and tendencies. I've had more migraines I think, but I have started menopause I think(just missed 2 periods so far this year)....
I had Foxomax for 1 week and Miacalcin (spray). The spray was wonderful, except that I developed nasal allergies, so I quit that. Now I don't know what to do, except exercise a lot more. There was great improvement due to these meds. and I felt very good about it. I also take calcium regularly and try to exercise more. - [Don't post personal details please....mod3]
[This message has been edited by moderator3 (edited 04-20-2002).]
My health is still excellent otherwise; I've always had very low cholesterol, so it prob. also depends on your body type and tendencies. I've had more migraines I think, but I have started menopause I think(just missed 2 periods so far this year)....
I had Foxomax for 1 week and Miacalcin (spray). The spray was wonderful, except that I developed nasal allergies, so I quit that. Now I don't know what to do, except exercise a lot more. There was great improvement due to these meds. and I felt very good about it. I also take calcium regularly and try to exercise more. - [Don't post personal details please....mod3]
[This message has been edited by moderator3 (edited 04-20-2002).]
bjg
04-21-2002, 11:13 AM
this message is for jir..i have literature from lilly the manufacturer of evista...it says "do not take evista if your dr has not told you that you have passed menopause...evista is for use only by women after menopause"..if you have just missed 2 periods it does not sound like evista is the right rx for you..thank you for responding to my ?
cstar
05-12-2002, 05:19 PM
I have been taking Evista for 2 months and am experiencing fatigue, and some nausea and weight lost. Doctor says it is not related to Evista, but it started about the time I started taking the Evista. Is anyone having any of these problems? Funny thing, I am not bothered by hot flashes or night sweats.
bjg
05-12-2002, 06:47 PM
i just started it last week ..so what side effects it brings are probably yet to be seen.. but you can call the manufacturer lilly at 800-545-5979 ..they have statics on what side effects were reported during the clinical trials........
cstar
05-25-2002, 06:38 PM
Called Lily about nausea etc. None of these side effects in the "clincial trials". No available data on people calling them like me. Decided to stop taking it to see if Evista was the problem. Fatigue still a problem, but nausea is better.
bjg
05-25-2002, 08:57 PM
you mite want to call lily back and let them know that since you have stopped taking it the nausea is better..it mite be useful info for someone else in the future who has that problem and calls them
Arlette
05-27-2002, 11:47 PM
I am experiencing severe leg pain. Also night hot flashes are nearly unbearable. should i take tylenol? Has anyone else had trouble w/ Evista?
arkie6
05-28-2002, 04:42 PM
This link discusses some of the risks associated with taking Evista: http://www.mercola.com/2002/mar/6/evista.htm
Here is an excerpt from the article:
"The drug's manufacturer, Lilly, with FDA's complicity, has suppressed critical information that this drug poses major risks of ovarian cancer.
In a study specifically designed by Lilly to prove the drug's safety, Evista was shown to induce ovarian cancer in both mice and rats. Moreover, carcinogenic effects were noted at dosages extending below the therapeutic.
However, the study concluded: "The clinical relevance of these tumor findings is not known." Lilly reached this conclusion despite the scientific consensus that the induction of cancer in well-designed studies in two species creates the strong presumption of human risk.
Nevertheless, Lilly failed to disclose this critical information in its "Warning" to women. Furthermore, no reference at all is made to these risks in a Lilly-sponsored publication on Evista in the December 4, 1997 issue of the New England Journal of Medicine.
Ovarian cancer is recognized as an uncommon complication of long-term hormone replacement therapy in the post-menopausal. Ovarian cancer strikes about 24,000 U.S. women every year, accounting for 4% of all their cancers. About 15,000 women die from ovarian cancer annually, making it the most lethal female reproductive cancer."
Here is an excerpt from the article:
"The drug's manufacturer, Lilly, with FDA's complicity, has suppressed critical information that this drug poses major risks of ovarian cancer.
In a study specifically designed by Lilly to prove the drug's safety, Evista was shown to induce ovarian cancer in both mice and rats. Moreover, carcinogenic effects were noted at dosages extending below the therapeutic.
However, the study concluded: "The clinical relevance of these tumor findings is not known." Lilly reached this conclusion despite the scientific consensus that the induction of cancer in well-designed studies in two species creates the strong presumption of human risk.
Nevertheless, Lilly failed to disclose this critical information in its "Warning" to women. Furthermore, no reference at all is made to these risks in a Lilly-sponsored publication on Evista in the December 4, 1997 issue of the New England Journal of Medicine.
Ovarian cancer is recognized as an uncommon complication of long-term hormone replacement therapy in the post-menopausal. Ovarian cancer strikes about 24,000 U.S. women every year, accounting for 4% of all their cancers. About 15,000 women die from ovarian cancer annually, making it the most lethal female reproductive cancer."
bjg
05-29-2002, 08:34 AM
Carcinogenesis: In a 21-month carcinogenicity study in mice, there was an increased incidence of
ovarian tumors in female animals given 9 to 242 mg/kg, which included benign and malignant tumors
of granulosa/theca cell origin and benign tumors of epithelial cell origin. Systemic exposure (AUC) of
raloxifene in this group was 0.3 to 34 times that in postmenopausal women administered a 60-mg dose.
There was also an increased incidence of testicular interstitial cell tumors and prostatic adenomas
and adenocarcinomas in males given 41 or 210 mg/kg (4.7 or 24 times the AUC in humans), and prostatic
leiomyoblastoma in males given 210 mg/kg.
In a 2-year carcinogenicity study in rats, an increased incidence in ovarian tumors of granulosa/theca cell
origin was observed in females given 279 mg/kg (approximately 400 times the AUC in humans). The
female rodents in these studies were treated during their reproductive lives when their ovaries were
functional and responsive to hormonal stimulation. The clinical relevance of these tumor findings is not
known. ...auc is area under the curve...i am not sure exactly how to interpret this .was the cancer seen in rats only when they were given significantly a higher dosage then is perscribed for humans???.i am calling lily today to see what they can tell me and i will be discussing it with my dr when i see in 2 weeks
ovarian tumors in female animals given 9 to 242 mg/kg, which included benign and malignant tumors
of granulosa/theca cell origin and benign tumors of epithelial cell origin. Systemic exposure (AUC) of
raloxifene in this group was 0.3 to 34 times that in postmenopausal women administered a 60-mg dose.
There was also an increased incidence of testicular interstitial cell tumors and prostatic adenomas
and adenocarcinomas in males given 41 or 210 mg/kg (4.7 or 24 times the AUC in humans), and prostatic
leiomyoblastoma in males given 210 mg/kg.
In a 2-year carcinogenicity study in rats, an increased incidence in ovarian tumors of granulosa/theca cell
origin was observed in females given 279 mg/kg (approximately 400 times the AUC in humans). The
female rodents in these studies were treated during their reproductive lives when their ovaries were
functional and responsive to hormonal stimulation. The clinical relevance of these tumor findings is not
known. ...auc is area under the curve...i am not sure exactly how to interpret this .was the cancer seen in rats only when they were given significantly a higher dosage then is perscribed for humans???.i am calling lily today to see what they can tell me and i will be discussing it with my dr when i see in 2 weeks
bjg
05-29-2002, 11:44 AM
i called lily ..evista has been on the market just over 4 yrs...not long enough in my mind to know what problems will surface with long term use..but i will give you the info that i have and you can draw your own conclusions...they are aware of the study that showed the connection between raloxifene(evista) and ovarian cancer in mice in rats that were given evista...however their clinical trials of evista being given to over 10,000 postmenopausal women showed no increase in ovarian cancer...and they are not aware of any increase in ovarian cancer in women who are taking the drug since it went on the market...lily does not feel that because mice and rats got cancer it is appropriate to extrapolate and assume the same will happen in postmenopausal women because it is not a fair comparison..the mice and rats have not gone thru menopause..which i have to say makes sense to me....bottom line i am going to talk to my dr and for now continue using evista...but i believe it is important for all of us to know all we can about this and any other drug we are taking so we can each decide for ourselves what is right for us.......
Lilybear
08-11-2003, 02:51 PM
[QUOTE]Originally posted by Arlette:
[B] I have been off of evista for about a month. I stopped it after experiencing sore and stiff knees and a feeling of antsy legs plus extreme hot flashes. I went to the Dr. and he gave me methylpred, a steroid drug, which I did not take because I am afraid of those side effects. He said it was like having a deep bruise that needed help to heal caused from the evista. I seem to be getting better each day, but I hope it goes away completely soon. Does anyone know how long this lasts?
[B] I have been off of evista for about a month. I stopped it after experiencing sore and stiff knees and a feeling of antsy legs plus extreme hot flashes. I went to the Dr. and he gave me methylpred, a steroid drug, which I did not take because I am afraid of those side effects. He said it was like having a deep bruise that needed help to heal caused from the evista. I seem to be getting better each day, but I hope it goes away completely soon. Does anyone know how long this lasts?
bjg
08-12-2003, 08:35 AM
i have been on evista 15 months..i just started having the sore and stiff knees and at times the antsy legs..im going to call lily 800-545-5979 and report it to them..would you do the same..they need to know what their product is causing..good luck to you
merryk
08-12-2003, 11:38 AM
I am on Evista and have had trouble with my knees lately. I have attributed it to my stepped up exercise which includes some stair climbing each day. I will cut back on this and see if it makes a difference. If not, I will also report it, so they are aware of a potential side effect.
I also had some vision problems which is listed on the Evista cautions. I went to see an ophthalmologist and it turns out I have the beginnings of a cataract, which both my parents had.
The blood clot warning is scary, but it keeps me moving and taking extra stops when in a car for longer periods of time.
I also had some vision problems which is listed on the Evista cautions. I went to see an ophthalmologist and it turns out I have the beginnings of a cataract, which both my parents had.
The blood clot warning is scary, but it keeps me moving and taking extra stops when in a car for longer periods of time.
bjg
08-12-2003, 06:46 PM
can you ladies pls tell me how long you were taking evista before you noticed the knee problems
merryk
08-13-2003, 10:57 AM
bjg:
My knees started bothering me about 8 months into taking Evista. It isn't like I have an injury because it is both of them. My job requires some bending and lifting, so it's not that I have gone from a sedentary life style to an active one in a short period of time, either.
My knees started bothering me about 8 months into taking Evista. It isn't like I have an injury because it is both of them. My job requires some bending and lifting, so it's not that I have gone from a sedentary life style to an active one in a short period of time, either.