At one time I was taking a drug (?forgot what) and after awhile I started in aching, terrible in my joints. I couldn't lift a dish out of the cupboard, unless I held my arm up with the other hand. After getting off the drug, I went back to normal. I'm sorry I can't remember more about it, for it was 20 some yrs ago, but you may have something there, with your question. Jmho.