I had 3 infusions of Remicade before I realized that I should have been ordering it through a specialty pharmacy my insurance requires rather than letting the doc bill for it. The insurance was only paying 1/2 and I had to stop because of $$$$. The sad part in all of this is that it works for me and I know it does. I just can't afford to do it the way every doctor I have seen insists on doing it. If you decide to try it, be absolutely sure that you are jumping through all the insurance hoops or you could get stuck with a big bill.
6 days after my first infusion I came wide awake as I lay in bed stretching before arising and realized that I had just made a complete fist and IT DIDNT" HURT!!! It just got better from there. I believe Remicade needs MTX in order to work maximally. I'm not sure if you can take it without it but I think you can. Remicade also treats Crohn's disease and I don't think those patients have to take MTX. It's something you could probably research or ask your doctor about.
A member of another board I visit started Remicade last year after years of RA and it literally has given him his life back. I'd take it again in a heartbeat and will if I can convince my rheum that my treatment is more important than his bottom line. The only side effects I noticed was being very tired (sort of like the fatigue of a flare) the afternoon of the infusion. It does knock out your immune system for 48-72 hours after an infusion so you need to avoid germy people during that time. I teach little kids and wore a mask when lots of them were germy and sharing those germs freely.