I am new to this board but have been lurking and also active on other boards but when I saw your question I thought I should tell you my experience with Methotrexate. I was diagnosed with RA last year, I am 59 yrs old, and I also have osteoarthritis, degenerative disc disease, severe osteoporosis. My first visit with the rheumatologist he put me on Methotrexate (15 mg)(every Sunday night) and 1 mg of Folic acid. I was hesitant about taking it when I read all the possible side effects but did it any way. I will admit that it did make me nauseous the day after taking it and I was really tired but the pain was really going away but I didn't know how much until I had to go off the methotrexate.
I ended up coming down with severe polynephritis (kidney infection) which was an e-coli bacteria and they think it was caused by my immune system being compromised due to the Methotrexate. The doctors said a normal person should have been able to fight off the infection but my immune system was in a terrible shape. I was really sick and in the hospital for a week and they told me I was very lucky to pull out of it. My rheumatologist didn't want to believe that the Methotrexate weakened my immune system but everything pointed to it. He asked me to take one more week of the medication and if I got sick then he would take me off of it. Well, I did and I got sick and I told him I wouldn't take it anymore. BUT I will say the pain was almost gone and now he doesn't know what to put me on so I am in terrible pain again. I know some people do not have any reactions to this medicine but I wanted to let you know what happened to me. I hope you can get on some medication and start feeling better soon.