I am 37 and have had RA for the past 5 years. I was on Humira for about 3 years but now take Orencia. Humira worked very well for me and I noticed the difference rather quickly. One thing I have to be honest about, though, is the injections were painful. I had my husband give me my injection because there was no way I could do it myself. I'll be honest, in only hurts for a few minutes, but for those few minutes it hurt alot. But, I have spoken to others who have said they didn't think the pain was bad at all, so they may be a breeze for you! I hope this helps!