Long term use of prednisone refers to taking the medication for long periods of time. For example, if a person has VERY severe asthma, emphysema, COPD or things of that nature, and ususally for the elderly with these conditions, prednisone is given as a regular medication, daily for years. On the other side, you have asthmatics or people who get respiratory infections who have to end up taking the medication in "bursts" for short periods of time, usually a week or so. This may happen one or two times per year, but that is usually NOT considered long term use. Hope that helps =)
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