11-17-2005, 06:33 AM
Join Date: Apr 2003
| | Carnosine seems to be useful in autism
Hi at all.
Have you tried the carnosine (not carnitine)?
Seem good (see below) at about 800 mg/day
Keep me informed about your results.
Domenico J Child Neurol. 2002 Nov;17(11):833-7.
Double-blind, placebo-controlled study of L-carnosine supplementation in
children with autistic spectrum disorders.
Chez MG, Buchanan CP, Aimonovitch MC, Becker M, Schaefer K, Black C, Komen J.
Research Division, Autism and Epilepsy Specialty Services of Illinois, Ltd, Lake
Bluff, IL 60044, USA. [email]firstname.lastname@example.org[/email]
L-Carnosine, a dipeptide, can enhance frontal lobe function or be
neuroprotective. It can also correlate with gamma-aminobutyric acid
(GABA)-homocarnosine interaction, with possible anticonvulsive effects. We
investigated 31 children with autistic spectrum disorders in an 8-week,
double-blinded study to determine if 800 mg L-carnosine daily would result in
observable changes versus placebo. Outcome measures were the Childhood Autism Rating Scale, the Gilliam Autism Rating Scale, the Expressive and ReceptiveOne-Word Picture Vocabulary tests, and Clinical Global Impressions of Change.
Children on placebo did not show statistically significant changes. After 8
weeks on L-carnosine, children showed statistically significant improvements on the Gilliam Autism Rating Scale (total score and the Behavior, Socialization,
and Communication subscales) and the Receptive One-Word Picture Vocabulary test (all P < .05). Improved trends were noted on other outcome measures. Although the mechanism of action of L-carnosine is not well understood, it may enhance neurologic function, perhaps in the enterorhinal or temporal cortex.