I've been taking cell cept because my immune system is way out of control; it expresses itself on my skin and the only relief I feel for years has been if I'm sneaking prednisone or have an ice pack held onto my face with an ace bandage. So after refusing cellcept for years I finally gave in. I started with 1000 mg daily, went to 2, down to 1500' now I' m back to 1,000. Like you, I'm exhausted and have a number of other side effects that are very bothersome. I'm going down to 500 on my own tomorrow, and I'll take what I can get with that. If the side effects continue, damn the torpedos, it will be full speed ahead with prednisone. I'm having a hip replacement in July, and I'm sure they won't do it with the cellcept side effects going on. Good luck!