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Old 10-02-2012, 09:28 AM   #1
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Scared and confused by conflicting ANA patterns

Hello,

I've been tooling around on these boards for 3.5 months now trying to see if anyone here would have some insight on what is going on with me.

Here we go.

1. Legs (shins and calves) begin to ache continually and I had major fatigue, went to see my GP.
2. ANA shows a 1:640 centromere pattern
3. Get sent to sclero clinic to see what the dealio is (I also have lichen sclerosis and morphea)
4. Doc determines she sees no outward manifestations of CREST and sends me to an endocrin for metabolism issues?
5. GP determines I have fibromyalgia.
6. Go to endocrin, he says he doesn't see anything other than the high ANA, sends me to a rheumy he suggests.
7. See new rheumy. Does a VERY thorough exam and says no arthritis but he wants to do more...testing.
8. All blood tests come back normal except for ANA which NOW come back as 1:1280 with speckled pattern.
9. legs and arms are still painful. Feel like I've run a marathon most days.

So...how do you have a centromere pattern one time and speckled the next?

The rheumy is going to do more detailed tests to try to determine what form of whatever I have.

I'm scared to death of both lupus and sclero. Slero especially...

Can a person have both a centromere issue and a speckled? I know centromere points to CREST, but what does speckled point to? Is it typically one thing over the other???

 
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Old 10-02-2012, 09:44 AM   #2
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Re: Scared and confused by conflicting ANA patterns

I have been researching the patterns of the blood. Mine is homogeous and speckled. What does that mean? I do not know. But to answer your question about having more then one pattern, I say yes because I know I do. I am going to see a rheum. next week. Anxious to see what they have to say.

 
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Old 10-02-2012, 10:21 AM   #3
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Re: Scared and confused by conflicting ANA patterns

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Originally Posted by Lynnypinny View Post
I have been researching the patterns of the blood. Mine is homogeous and speckled. What does that mean? I do not know. But to answer your question about having more then one pattern, I say yes because I know I do. I am going to see a rheum. next week. Anxious to see what they have to say.
I have no manifestations of CREST except for the Raynauds. The rheumy thinks I may be getting a reading for anticentromere for that or even the morphea.

The speckled...well...who knows.

Lynn, If I could hug you, I'd hug you big time, we'd have a good howl at the circumstances and then go buy shoes.

I'm just so very sad. I know it isn't a "death sentence" per se, but it sure is frightening. very

 
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Old 10-02-2012, 10:36 AM   #4
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Re: Scared and confused by conflicting ANA patterns

Centromere and Speckled can be misread as one another. You can actually be tested for the anticentromere antibodies, but that may be from your morphea. I can't remember if you said you had Raynaud's or not. Calcinosis, Raynaud's syndrome, Esophogeal dysmotility, Sclerodactyly, Telangiectasia) formerly known as CREST, you have to show at least 3 of these plus labs to be diagnosed with. Anticentromere also shows up in PBC and UCTD. Speckled shows up in a lot of different things such as SLE, Sjogren syndrome, scleroderma, polymyositis, rheumatoid arthritis, and mixed connective tissue disease but again, could be due to morphea. Also patterns can change. It is good that your new rheumy is doing additional testing.

 
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Old 10-02-2012, 11:32 AM   #5
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Re: Scared and confused by conflicting ANA patterns

Luca,

I have had raynauds for...forever. I'm 53 and can't remember a time when I didn't have it. It got worse in my early 30's.

The new rheumy is determined. I like determined. I feel if we are being proactive at least...that's something.

As for the CREST...I do not have skin manifestations like telangiectasia (oh I have like 15 or so but they are all over, one on my leg, one on my chest, one on my hip etc). I do not have calcinosis or sclerodactyly. The sclero specialist did a nail fold test with a negative result and let me tell you, the wrinkled hands I used to complain about, I now look at with admiration!

What is PBC and UCTD?

 
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Old 10-02-2012, 11:34 AM   #6
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Re: Scared and confused by conflicting ANA patterns

PBC...scary. My dad and grandfather died of cryptogenic liver disease. I have mild fatty liver disease, but am thinking of asking for a biopsy to rule out anything else.

 
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Old 10-02-2012, 11:56 AM   #7
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Re: Scared and confused by conflicting ANA patterns

A negative nailfold test is wonderful news! And Like I said before, I have too many telangiectasia to count, and on my chest, they look like a permanent red rash. PBC = primary biliary cirrhosis and UCTD = undifferentiated connective tissue disease.

 
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Old 10-02-2012, 12:30 PM   #8
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Re: Scared and confused by conflicting ANA patterns

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A negative nailfold test is wonderful news! And Like I said before, I have too many telangiectasia to count, and on my chest, they look like a permanent red rash. PBC = primary biliary cirrhosis and UCTD = undifferentiated connective tissue disease.
My shin/calf pain is so bad it keeps me up at night. Other than that, headaches (ok, admittedly it could be stress or sinus related) is my other symptom.

My legs are awful Sometimes I have arm pain (from elbows down) that is the same.

I don't think they think it is PBC, I saw a hepatologist a month ago.

I just want to maybe feel a little better?

I have brown freckles covering my body and then there are the white ones (vitiligo) I am the walkikng autoimmune model that is mottled

 
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Old 10-02-2012, 12:56 PM   #9
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Re: Scared and confused by conflicting ANA patterns

If it makes ya feel better, I have the sclero salt and pepper coloured skin with red dots sprinkled throughout and my hair started going white in my teens, lol.

 
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