Re: Undiagnosed: Hives, Joint aches, Extreme Fatique
Hi & welcome. I'm only a patient, so please read this accordingly.
Were shingles ruled out? While shingles favor older people, they can occur at any age. (But I'm guessing this is unlikely: shingles rashes respect the center line of the body, and you'd have both noticed that peculiarity.)
I think I've read that rashes re-erupt in some people with Lyme disease. Was he tested for it?
Does he take any meds regularly? Simple skin reactions are, of course, relatively common, but some meds can cause more than rashes in susceptible people. Joint pain, fatigue, etc. are seen in the form of lupus called Drug-Induced Lupus Erythematosus (DILE), a form that's milder than systemic lupus (SLE). "Treatment" for DILE consists of identifying the culprit drug(s) and discontinuing them. Meds that have been implicated in DILE include some very common ones like cholesterol meds, blood presssure meds, certain antibiotics, etc. Hallmarks are positive ANA, positive anti-single-stranded-DNA, and positive antihistone.
Re: other autoimmunes. There were recent discussions on this board about hives & autoimmunity. To locate them, you could click the link "Search This Board" and type in "hives". And to search across all the boards at once, you could try the "Advanced Search" link.
If nothing else pans out, I'd maybe try an infectious disease specialist.
I wish I knew more! Hopefully others will weigh in soon. Best wishes, Vee