Re: Night spasms/cramps in thigh and buttock - what causes this?
Yes, I was told to take Zanaflex, but that really didn't help and I still woke up after about 3 hours in pain. I find Tylenol PM helps me to get at few more hours without the grogginess of the Zanaflex. It is really the Benadryl (antihistamine) in the PM that causes the drowsiness, but I don't know the long term effects of taking it. Also, the doc suggested an antidepressant Amitriptylene, but I am leary of these off label things, tho it seems to help others.