I recently had intravenous prednizone followed by 5 days orally. This was after a trip to emergency when a herniated disc at L5/S1 that has fragmented, rendered me imobile and in indescribable pain. I am waiting now to have a microdiscectomy. However...I think the predinzone has likley helped with the inflammation, as currently, I have little pain....mostly achiness and the irritating feeling of the numbness and weakness. I do think the prednizone will attack the inflammation of irritated nerve roots, etc. I don't know how long it lasts and it likely isn't as good as an ESI injection, but it is often a first course of treatment. That's what I can offer from my experience. Hope it will help you.