Hey M* good question,
My PDr. told me to nudge my meds in either direction until I found the right "blend" for me. If I do boop my meds in either direction I do it slowly.
In reference to resistance to meds, I too have a hard time. It seems ANY KIND of med works rather well for me in the beginning but after a few months they stop working...
My Oncologist says this is because we have such efficient livers...apparently our livers start to recognize the unwanted toxins (Our Meds) and creates an enzyme to neutralize them, hence they stop working...
Who knows if he's got the answer, I'm not a chemist or biologist.
Anyway, I've not been feeling too well...darn arthritis....I took a Darvocet to ease the pain and it always screws up my depression....It takes me a couple days to get back on track.
{{{Hugs to All}}}
Terry