| | Weight Gain on Geodon + Lamictal for Bipolar Type II
I started on atypical antipsychotics about five years ago to treat refractory depression incident to bipolar type II. Over the course of the following four years, my weight increased by 70%! I went off atypicals about nine months ago and at the same time went on Lamictal. Soon after, the weight started dropping off, almost without my trying; I'm now only about 40% heavier than my starting weight. But the depression has barely lifted.
I have a new pdoc who started me on Geodon, another atypical. He swore to me that there are no studies showing weight gain with Geodon. But when I got home I looked at Pfizer's (the manufacturer's) web site and they cite two different clinical trials that show 1.5-6% of patients (give or take) experience significant weight gain beyond the rate experienced by placebo groups, as well as one study on bipolar maintenance that showed no difference between treatment and placebo groups. After three weeks on Geodon, I've gained five pounds; this after more than six months of steady losses. I'm pretty irked.
Although some of the evidence referred to use of Geodon in combination with other drugs, none mentioned the combination of Lamictal and Geodon. None of the trials were specifically studying non-manic bipolar maintenance treatment or bipolar type II. Does anyone else have experience with Geodon, Lamictal, and weight gain or know of evidence that no patient has ever gained signficant weight when Geodon is combined with Lamictal?