Yes, the pill (any bc pill) can make you moody or depressed. Sometimes it goes away, sometimes not, it depends on the person. If it doesn't go away after 3 or 4 months, I'd say switch to a different one. I'm currently on Ovcon-35 for the second time, starting my 8th month. I don't have any depression with it this time. However, the first time around I was depressed for the entire time I was on it (four months), so I went off of it.