Any type of inflammation anywhere in the body can cause this to happen. When I was 45 and diagnosed with moderate anemia, I also had a Sed Rate of 49 and for my age at the time it should be 20 or less. My Rheumey said that in my case it was related to inflammation in my thyroid because I also have Hashi's Thyroiditis which causes inflammation in the thyriod gland. This test is very non specific and if elevated then you should follow up with the CRP test, that is what my doc did for me and that test was normal. FLFG