If you're refering to a punch biopsy....
My personal opinion. It's not that bad if you relax your body at the time.
They took 3 "punch" out of me, and it wasn't bad at all. It all boils down to what you compare that feeling with. I compare that experience with a broken ankle,,,i'll take punch biopsy over that any day!
It's not worth the worry.
(I sure do know it's hard not to worry, but, do your best
As for pain killers, just take some over the counter pain killers. Something that does NOT thin your blood. Ask your pharmacist.