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Old 08-27-2009, 02:33 PM   #1
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Atypical Glandular Cells

Hi there.

I had an abnormal pap in 2005 and tested positive for HPV. Had a cervical biopsy which came back negative for cancer. Diagnosed with mild dysplasia.

Last week i got a call for the OBGYN and was told I had another abnormal pap showing mild abnormal cells and Atypical Glandular Cells.
They scheduled an endocervical cuttergae and endocervicall biopsy. I had that done yesterday, which for me, hurt like no bodies business!

So I am waiting on the results.

I have been doing a lot of reading, and I am wondering two things. Should I have gone straight to an OBGYN/ONCOLOGIST?
and other then cancer, what would cause Atypical Glandular Cells?

I am 38 years old. I have been on birth control for 15 years. I have no children and do not want children. I had my tubes tied in 1999. I remain on the pill because of very irregular periods.

Oh, one more question - has anyone experienced swelling of the vagina after their endocervical cuttergae and biopsy?


Any comments greatly appreciated.

 
Old 08-27-2009, 05:41 PM   #2
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Re: Atypical Glandular Cells

Hi Tracievh, I'm glad your doctor did a good followup after finding the AGS on the pap!

As far as I know, HPV is the only thing that causes AGS.

It is possible that your doctor will be consulting with a gyn/onc between now and your follow up appointment. I suggest you start looking into which gyn/oncs are on your insurance (if you have it).

This is what happened with me.

I had my regular, annual pap (thin prep) and it came back normal (they've been good for over 25 years). For the first time, my doctor also did the HPV/dna test. It came back positive for high risk HPV. I went to a ob/gyn and she did a colpo and ECC. The colpo showed no problems, but the ECC came back "atypical glandular epithelial lesions and suspected adenocarcinoma in situ." She did a cold knife cone (CKC) biopsy which diagnosed adenocarcinoma (AdCA) stage Ia1. After the colpo and after the CKC I called the doctor's office after 3-5 days to ask for results. Both times the results were there by day 5. So I got my results over the phone (which helped move along the diagnosis and treatment). I am SO glad I called. It let me be prepared for the results. I was sitting, had paper an pencil to take notes. I wasn't preoccupied or interrupted. I always recommend calling for results now.

After my AdCA diagnosis, but before my official follow up appointment, I called the gyn/onc offices in my city. I called one and the nurse was very nice and informative. After talking for about 10 minutes she asked for my name again and said she already had all of my paper work and I could schedule the appointment. I went to it instead of my regularly scheduled post CKC followup!

Long story short (HA!, I know it is already long), I ended up having a total hysterectomy (uterus and cervix only) by LAVH (lap assisted vag hyst). That was in June last year. Since then, I've had 4 or 5 follow up appointments. When I went in July, my doctor released me to going back to my GP for my paps (I'll have to have a smear every year forever, but at least I don't have cancer now!). I do not need (nor did I) chemo or radiation.

My doctor said she was releasing me after only a year (I thought I'd have to have 5 years of followup exams) because the cancer was found SO early (because of the HPV/dna test and the ECC) and she removed all of those glandular cells.

I feel blessed that my cancer was found so early and that my treatment plan only involved a hysterectomy (and many, many, many nights of lost sleep and worry). I was 44 when I was diagnosed and never had children (partly by chance and partly by choice). So all turned out really well.

Oh, and normally, a gyn/onc won't take a woman as a patient until she has CIN III (severe dysplasia), AIS or CIS, or cancer. So, I'd say now is the time for you to be looking into your gyn/onc options.

There is one woman here (on this part of HB) who had severe swelling after her colpo. Her doctor told her it wasn't possible, but she went to a specialist who said it was absolutely possible to be allergic to the preservatives in the solutions they use. I don't know how bad your swelling is, but maybe an antihystamine like benadryl would help reduce the swelling.

I hope you are feeling ok, physically and emotionally. It is a huge roller coaster of emotions. It is totally normal.

(((((((((hugs))))))))))) to you!

 
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Old 08-28-2009, 06:46 AM   #3
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Re: Atypical Glandular Cells

Welcome Tracie! I am glad you came to this site.

I think we're all pretty much in agreement here that anyone with glandular changes should go to a gyn/onc. Ob/gyns see this stuff so rarely, and just from women on this site there have been a bunch that haven't been given the best treatment by their ob/gyns. So us telling you to go the the gyn/onc, we aren't saying you have cancer, but that is usually the best place.

And I think Pickle was referring to me about the swelling! I had TERRIBLE swelling after my colposcopy with biopsy and was told that it must have been a "psychological" reaction. I'm not sure exactly what you experienced, but I was swelling during the procedure. Having the speculum in while having your vagina swelling shut is NOT fun!! I think it may have been a reaction to one of the solutions they put in you during the procedure. For me the swelling started to go down in a couple of days and I was back to normal in about a week.

 
Old 08-28-2009, 11:18 AM   #4
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Re: Atypical Glandular Cells

Thank you for responses.
I guess the good thing is that my insurance does not require a referral. So after i get my results, I will call an gyn/onc. I didn't realize that regular gyn's did not have much experience in this scenario.

As far as my swelling, it was the next day. Luckily, today is MUCH better! I feel so relieved about that. I hope that i never have to go through that procedure again. For me it was horrible.

I had read that atypical glandular cells are never caused by HPV. But it was on the internet so you know how that goes

 
Old 08-28-2009, 07:09 PM   #5
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Re: Atypical Glandular Cells

Quote:
Originally Posted by tracievh View Post
I had read that atypical glandular cells are never caused by HPV. But it was on the internet so you know how that goes
Really?

Wow.

In all of my research when I was diagnosed, every site kept saying it was caused by HPV. My gyn/onc also says it is. I tried to stick with sources like the Center for Disease Control, cancer societies, and sites they link to. I went to discussion boards for emotional support, not facts/details.

Let us know how you are doing! (((hugs)))

 
Old 08-31-2009, 04:38 AM   #6
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Re: Atypical Glandular Cells

Quote:
Originally Posted by Pickle Eyes View Post
Really?

Wow.

In all of my research when I was diagnosed, every site kept saying it was caused by HPV. My gyn/onc also says it is. I tried to stick with sources like the Center for Disease Control, cancer societies, and sites they link to. I went to discussion boards for emotional support, not facts/details.

Let us know how you are doing! (((hugs)))
I tried to find the site where i read ( or thought I read ) that info but couldn't find it. I did see a lot of references about it is not always caused by HPV. It may have been that i mis-read it or was just totally over-whelmed with all the info i had been researching and reading.

I feel 110% better today. Now I just have to wait for the results to come in! i think that if i don't hear fro them by Wednesday i will take your suggestion to call them.

 
Old 08-31-2009, 05:14 PM   #7
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Re: Atypical Glandular Cells

Quote:
Originally Posted by tracievh View Post
I feel 110% better today. Now I just have to wait for the results to come in! i think that if i don't hear fro them by Wednesday i will take your suggestion to call them.
I am so glad to hear that!

Let us know how the results come back! (((hugs)))

 
Old 09-02-2009, 02:57 PM   #8
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Re: Atypical Glandular Cells

Quote:
Originally Posted by Pickle Eyes View Post
I am so glad to hear that!

Let us know how the results come back! (((hugs)))
I just off the phone with my gyn. She said that the ecc and uterus biopsy were negative. One of my cervix biopsies showed mild dysplasia the other two were CIN III. She wants to do a leep.

Fine.

I asked her about the atypical glandular cells and what the origin was and she said they were most likely from my cervix where I had the CIN III ?? Iím confused by this. I thought those cells were only found inside the cervical canal or higher up? I also recall reading that if AGC were found on a pap and biopsies came back negative that a cone biopsy must been done.

Iím thinking I need a second opinion on the glandular stuff.

What do you think?

 
Old 09-02-2009, 08:43 PM   #9
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Re: Atypical Glandular Cells

I think either another EE might be called for or possibly some sort of cone, probably a cold knife cone.

I'd definately seek a second opinion since you are questioning the doctor's ideas.

 
Old 09-03-2009, 03:55 AM   #10
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Re: Atypical Glandular Cells

Quote:
Originally Posted by Pickle Eyes View Post
I think either another EE might be called for or possibly some sort of cone, probably a cold knife cone.

I'd definately seek a second opinion since you are questioning the doctor's ideas.
gosh, i really don't want to do another ecc, that was just a nightmare for me. I'm going to call today about a second opinion from a gyn/onc that was recommend to me last night by a friend of a friend.

I'm still worried about the glandular stuff though. Guess it does no good to worry over something until i know what to worry about

 
Old 09-05-2009, 07:33 PM   #11
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Re: Atypical Glandular Cells

I would get a 2nd opinion, gladular cells only occur in 5% of paps, even doctors do not know all the ends and outs.

They are very aggessive and do not take any time at all to develop in to cancer.

Best of luck to you

***It was late when I read your post. A leep can tell if the margins are clear or not. It is a very easy non painful option. I had a leep first and it cleared all margins the gyn-onc was fine with that, I did however go on to have a cone for my piece of mind*****

2nd opin never hurt though, main thing is whatever it is you are taking care of it and its early........You will be fine for sure, no worries

Last edited by jacmay; 09-06-2009 at 07:22 AM.

 
Old 09-06-2009, 06:43 AM   #12
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Re: Atypical Glandular Cells

Hi Tracie --

If you are having a LEEP, then any glandular problems should be detected from that surgery. A CKC would give better edges to read if you have close margins, but a LEEP will show what's going on in the tissue. There are several people on this board that had AIS diagnosied "accidentally" when they went in for a LEEP.

Good luck, and keep us posted as to what's going on!

 
Old 09-10-2009, 02:47 PM   #13
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Re: Atypical Glandular Cells

Quote:
Originally Posted by zoe96 View Post
Hi Tracie --

If you are having a LEEP, then any glandular problems should be detected from that surgery. A CKC would give better edges to read if you have close margins, but a LEEP will show what's going on in the tissue. There are several people on this board that had AIS diagnosied "accidentally" when they went in for a LEEP.

Good luck, and keep us posted as to what's going on!
Thanks!

I went and saw an gyn/onc to be on the safe aide and he explained the atypical glandular cells to me so very well. It really made sense. he said that a lesion is often only 1 cm inside the cervical canal, so the LEEP would pick it up, and that if that biopsy showed something bad, chances are I'd have to do the cone and then a hysterectomy anyways.

So now its just a waiting game I guess. I hate waiting. My LEEP is schedule with the reg gyn on the 23rd on this month.

I'm wondering if i should change that though because i have an even to attend that weekend and not sure what kind of recovery or 'after-effects' i might have.

 
Old 09-10-2009, 03:03 PM   #14
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Re: Atypical Glandular Cells

The 23rd is a Wednesday, right? I think you'd be fine to do anything that weekend, as long as it wasn't too strenuous.

 
Old 09-11-2009, 10:47 AM   #15
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Re: Atypical Glandular Cells

yes, it is a wednesday. I'm worried because when i had my col/ecc and biopsy ( it was a wednesday ) i started getting a discharge that saturday and it about ruined my day. I was at an event that weekend too.

I had a lot of pain when i had the ecc done, wondering if LEEP is the same?

 
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