Tarceva/Cellebrex - combination therapy
Hello everyone - I just thought I would take a moment and share the latest development in Patsy's treatment. About 5 weeks ago Patsy started Tarceva (150 mg) once a day. Fortunately the side effects have been minimal. However there has yet been no obvious signs that it might be working, as she has not been feeling well and a swollen lymph node appeared. Some weeks ago I ran across an article on a clinical trials that paired Tarceva with Cellebrex, an anti-inflamatory drug for bone disease that inhibits the COX-2 enzyme. Generally about 10% of nsclc patients who try Tarceva respond it, but according to the trial adding Cellebrex upped the response rate from 10% to 33%. It was hypothesised that an excess of COX-2 (not uncommon in LC) could be interferring with the Tarceva, thus Cellebrex, a COX-2 inhibitor could be effective in removing the obstacle. So I brought it up with our oncologists and they agreed it was worth trying. I will start her on it tommorow and we will go back on the 23rd of March for a CT and examination.
Our clinic is at the Medical University of South Carolina, a teaching hospital. Our onc told us that they were conducting several clinical trials using Cellebrex in combination with other cancer therapies. Sorry ...I don't know any details. However, from what I have been learing about convetional treatments, "combination therapies" seems to be the wave of future research. Not so long ago "combination therapies" were considered to risky, but now are common place.
I noticed you haven't been on in a while which has me concerned. If you get a moment, let us know how Stan is doing ...and how you are doing.