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Old 04-07-2010, 09:23 AM   #1
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bmwidd HB User
Question Cediranib Clinical Trial?

Hi, my father was diagnosed with stage III non-small cell lung cancer about 7 months ago and had one lung removed about 5 months ago. Initially we were told that they got everything and that that was the end of things and his surgeon never referred him to an oncologist after the surgery. After a couple of follow-up meetings with his surgeon, they suggested seeing and oncologist and we just started seeing one a few months ago. He feels great and has recovered very well (aside from some expected shortness of breath), but through recent CT scans, they are now suspicious about a small spot on his rib, some enlarged lymph nodes in his chest and a spot in his liver. It's a bit frustrating for all of us that it wasn't caught sooner, but they are suggesting that he consider participating in a clinical trial with an experimental drug called Cediranib (AZD2171). The clinical trial is in phase 3, but is not yet approved by any of the governing health bodies in Canada and the cost is being covered by the drug company (I'm assuming). Has anyone out there had any experience with this? They want to provide Carboplatin and Paclitaxel chemo drugs once every 3 weeks along with daily tablets of this experimental drug.

Thanks!

 
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Old 04-13-2010, 06:53 PM   #2
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Re: Cediranib Clinical Trial?

Hi: I think the trial you are referring to is this one: http://clinicaltrials.gov/ct2/show/NCT00795340

As to whether or not this makes sense - I can't say as I am not an oncologist. In general it seems that the drug is going to try to compete with Avastin or other inhibitors.

This article seems to indicate that the drug toxicity are manageable: http://www.ncbi.nlm.nih.gov/pubmed/19091548

Good luck to you all.

 
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