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Cancer: Prostate Message Board
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Old 05-19-2010, 07:03 PM   #1
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FSH & LH Levels

Back in February my husbands doctor added Flutamide after trying Siterone(failed) & casodex (failed). His 1st blood test since then came in with a PSA drop to 3.22(1st drop since 12/07) which is most exciting, testoterone down to 0.6, LH 1.8, FSH 7.1. I wondered if anyone knows what the levels of LH & FSH should be after having a orchidectomy.

 
Old 05-20-2010, 05:49 PM   #2
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Re: FSH & LH Levels

Hi Ann,

I don't know the levels of LH and FSH you would want after an orchidectomy (as you requested in the post I've copied below). You could search www.pubmed.gov for " orchidectomy AND LH AND prostate cancer ". I just did that and got 154 hits, including at least one free paper (hit #3). That paper was a study that showed soaring LH (up about seven times base value) and FSH (up about ten times base) at one year after orchidectomy (same as orchiectomy). Hit #19 pointed out that medical castration decreased LH and FSH while orchidectomy increased both. (You would expect that for an LHRH agonist drug, as it overstimulates the LH producing gland (pituitary), tricking the body into sensing an oversupply of testosterone, thereby inducing the body to shut down production of testosterone by shutting down production of LH, the messenger to the testes to produce testosterone.) There's a nice chart in the Primer, page 134. If you spend some time on those PubMed hits you may be able to figure out the levels. Hit 3 looks like a good bet.

Back in September you had asked for information on Proscar (finasteride), and I had missed your request. Try a simple search on www.pubmed.gov : " prostate cancer AND finasteride " (without the quotation marks). I just did that and got 530 hits - perhaps a few too many, but you may want to dig. However, you can find the three papers by one of the leading groups by using this search " prostate cancer AND finasteride AND scholz [au] ". That first (most recent) paper is especially worthwhile, but it is difficult to understand. I've studied it and can help if you have questions.

Take care,

Jim

Quote:
Originally Posted by dairywoman30 View Post
Back in February my husbands doctor added Flutamide after trying Siterone(failed) & casodex (failed). His 1st blood test since then came in with a PSA drop to 3.22(1st drop since 12/07) which is most exciting, testoterone down to 0.6, LH 1.8, FSH 7.1. I wondered if anyone knows what the levels of LH & FSH should be after having a orchidectomy.

 
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Old 05-20-2010, 08:10 PM   #3
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Re: FSH & LH Levels

Hi Jim,
Once again I thank you for giving so freely of your time.
We are going to specialists next week (3 monthly check-up) and have been wondering about sending him the papers on finasteride, by e-mail, so that he has time to read and consider and hopefully approve of adding this to treatment. It's 12 months since we last brought it up. Would really like to see testosterone as low as possible and this latest reading is about the same as his lowest reading back in June 06.

Thanks once again,
Ann

 
Old 05-21-2010, 09:38 AM   #4
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Re: FSH & LH Levels

Good morning (perhaps night to you) Ann,

First, you're welcome. I'm very glad to try to help.

It's a good idea to send him the papers in advance, and maybe follow up with a phone call. That 2006 paper on "testosterone inactivating pharmaceuticals" is very important, but the terminology can be hard to follow, probably even for a medical person . I've studied it, understand it, and have a copy of the paper, so I could probably help answer questions. One of the strong points of the paper is that it was published in the prestigious, peer-reviewed "Journal of Urology". The 2007 paper was published in another prestigious, peer-reviewed juornal, "Urology", so it has that same strong point for credibility. I provided several papers in advance to my oncologist about this advanced kind of therapy so that he could become familiar with it.

PCRI, a non-profit organization (the Prostate Cancer Research Institute) was co-founded by Drs. Strum and Scholz, major authors of these papers, and much of their findings and thoughts has been published by PCRI. Some of the key work is in articles published in the PCRI Insights newsletter. All this is available for free, and the text is written for patients, so it is a lot more understandable than the text in the medical papers. You might want to check some of those publications too.

I got to meet a woman from New Zealand last month at the annual meeting of the American Association for Cancer Research (AACR) here in Washington, DC, where both she and I were among the group of about thirty eight survivors who were representing cancer survivors of many types of cancer in the AACR's Scientist↔Survivor Program. We can't mention full names on this board, but I can say she was Chris W from Wiatarere Beach, Levin, NZ. Chris actually has a PhD and is an RN, unlike me (no enrolled medical education). She represented the "Breast Cancer Aotearoa Coalition. I enjoyed talking to her, but I did not envy her the jet lag she had to overcome to attend the conference. (We also had survivors from Jordan, Hungary, and Tanzania (a prostate cancer survivor), and survivors from Scotland and Sweden could not make it due to the volcano.) I particularly remember her brief talk that explained her poster about her organization and work as a survivor educator and advocate. I'm looking forward to writing a number of posts about experiences as an SSP participant. Trying to soak in all that knowledge was like trying to get a drink from a fire hose , but it was an awesome program. (The meeting is also one of the main reasons I've been kind of quiet on the board lately - some preparation, five days of intense participation, then recovery, sorting out what I picked up, attending to neglected chores at home and making up for time away from my usual activities.) There were 17,800 attendees - most from North America but many from other areas, almost all of them (except us) researchers or researcher/physicians. While we learn a great deal from them, I'm still impressed that we survivors have many insights, facts, and perspectives that the researchers need to hear and actually welcome. It's the third time I've attended.

By the way, on another note, Dr. Snuffy Myers is feeling more comfortable with dairy products and prostate cancer. While he still feels they add a bit to the risk, he also feels that emerging evidence is indicating that added risk is fairly low, particularly if the cows or goats are not fed much corn (affects the Omega 6/Omega 3 fatty acid balance). At a neighborhood restaurant I had a dish with a little cheese in it to celebrate when I saw that in his newsletter.

Take care,

Jim

 
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