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Old 08-20-2010, 11:45 AM   #1
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Roger Ali HB User
Casodex failed- now on Stilbestrol

Has anyone used Stilbestrol? I just completed 28 days of Casodex 50mg and my PSA increased from 7.1 to 9.3. As a result my urologist is is putting me on Stilbestrol next week. Please let me know of your experience particularly with respect to side effects. I'm in my 5th year after Brachy. I am 57.

 
Old 09-06-2010, 06:08 AM   #2
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Re: Casodex failed- now on Stilbestrol

Hi Roger Ali,

I have no experience in HT neither on the use of Stilbestrol. I got the following information which may give you an insight into the drug’s action and side effects, taken from trials;

Intravenous estrogens (fosfestrol or stilbestrol disphosphate)

Stilbestrol diphosphate (Stilphosterol®) is a water-soluble formulation of nonsteroidal estrogen that can be injected intravenously. High-dose intravenous estrogens are thought to have a direct cytotoxic effect on the prostate cancer cell. In theory, stilbestrol diphosphate enters the cell and free stilbestrol is liberated by an enzymatic action within the cancer. This enzyme, acid phosphatase is abundant in malignant prostatic tissue and releases free stilbestrol via dephosphorylation. Within the cell, DES destroys the cell by inducing apoptosis (programmed cell suicide).

Side effects consisted of perinea discomfort, nausea, vomiting and bone pain in some patients with widespread bony metastases. No cardiovascular or thrombotic complications were reported

Hope this helps, take care.
Baptista

 
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Old 09-09-2010, 04:38 AM   #3
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Re: Casodex failed- now on Stilbestrol

Hi Roger Ali,

I would like to add that Stilbestrol is also known as DES (diethyl stilbestrol). I read that in some cases it provokes heavy vommiting.
Just look in the net for DES.
< edited >
Wishing you the best,
Baptista

Last edited by hb-mod; 09-09-2010 at 07:29 AM. Reason: Please don't post unapproved websites, per Posting Policy. Thanks!

 
Old 09-09-2010, 03:04 PM   #4
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Re: Casodex failed- now on Stilbestrol

Please keep us updated, as I have been told that this is the next course of action for my husband.
Good luck and God speed,
Ann

 
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