Re: Casodex failed- now on Stilbestrol
Hi Roger Ali,
I have no experience in HT neither on the use of Stilbestrol. I got the following information which may give you an insight into the drug’s action and side effects, taken from trials;
Intravenous estrogens (fosfestrol or stilbestrol disphosphate)
Stilbestrol diphosphate (Stilphosterol®) is a water-soluble formulation of nonsteroidal estrogen that can be injected intravenously. High-dose intravenous estrogens are thought to have a direct cytotoxic effect on the prostate cancer cell. In theory, stilbestrol diphosphate enters the cell and free stilbestrol is liberated by an enzymatic action within the cancer. This enzyme, acid phosphatase is abundant in malignant prostatic tissue and releases free stilbestrol via dephosphorylation. Within the cell, DES destroys the cell by inducing apoptosis (programmed cell suicide).
Side effects consisted of perinea discomfort, nausea, vomiting and bone pain in some patients with widespread bony metastases. No cardiovascular or thrombotic complications were reported
Hope this helps, take care.