Re: p.s.a test
PSA bounce has many factors, patient age, younger tend to have higher bounces, lower RT dose tends to have higher bounces, Brachytherapy (seeds) tends to have higher bounces than IMRT. What is a bounce and what is recurrence, is the million dollar question. The definition of recurrence changes with information. Tricky question as the definition changes with new information for various treatments. It takes years to develop and analyze the data, in the mean time the dose is increasing and planning more focused. Testing our PSA every month is of little value unless there was a large increase of 1.4 to 2 ng/mL or more. Changes of 0.4 ng/mL are typical and not considered a failure unless the PSA continues to increase over 6-9 months. I am in a clinical trial (CyberKnife) where the PSA is checked every 3 months. There are many publications on pubmd about PSA bounce and radiation.