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Old 09-03-2010, 01:50 PM   #1
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Metformin and pca

Has anyone used or is familiar with literature regarding METHFORMIN and PCa? The internet is not real helpful thus far.

 
Old 09-04-2010, 12:05 AM   #2
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Re: Metformin and pca

Metformin (Glucophage) seems to have a small effect when used on its own:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767519/?tool=pubmed

but it may be better at inducing apoptosis when used along with 2-deoxyglucose:

http://www.ncbi.nlm.nih.gov/pubmed/20215500

 
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Old 09-04-2010, 10:05 AM   #3
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Re: Metformin and pca

Quote:
Originally Posted by Tall Allen View Post
Metformin (Glucophage) seems to have a small effect when used on its own:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767519/?tool=pubmed

but it may be better at inducing apoptosis when used along with 2-deoxyglucose:

http://www.ncbi.nlm.nih.gov/pubmed/20215500
Thank you for response.

What I am wondering given how it why it works is the effect on Human Growth Hormone (HGH). It should diminish it and therefore reduce this potentially fuel source for PCa. Has anyone reading this thread used it or know of studies that have incorporated it. It seems to me it is one of those neutral to prositive rather than neutral to negative opportunities.

Last edited by RBK1111; 09-04-2010 at 10:06 AM.

 
Old 09-04-2010, 10:50 AM   #4
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Re: Metformin and pca

I have not seen anything implicating human growth hormone in prostate cancer directly, although it does seem that IGF-1 can play some role and that in turn can be increased by hGH. Somatostatin is a much more powerful way to block hGH. In the research study quoted above, metformin seems to work through entirely different pathways. Why would anyone who is not diabetic want to take metformin and induce hypoglycemia? There are several drugs and supplements that show some promise in preventing it and/or slowing it down (e.g., finasteride, statins, cox2 inhibitors, soy isoflavones, curcumin, EGCG, quercetin to name just a few).

 
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Old 09-06-2010, 11:01 PM   #5
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Re: Metformin and pca

Quote:
Originally Posted by RBK1111 View Post
Has anyone used or is familiar with literature regarding METHFORMIN and PCa? The internet is not real helpful thus far.
Hi, RBK,
I saw a quote from a National Cancer Institute doctor saying that there is evidence that Metformin may reduce the risk of cancer across a broad range of cancers. I read other comments not so convinced, but indicating if a patient was taking medication for DM2, he might want to "lean" toward Metformin because of possible benefits for inhibiting growth of cancer cells. One study showed it was a big help to mice (who "smoked") worried about lung cancer...and clinical studies were being organized for breast and prostate cancer. An study of a few Japanese subjects had encouraging results. So it sounds like one might get a bonus of cancer inhibiting benefit (even though of yet to be determined quantity) if he is taking Metformin to treat his diabetes. Maybe future testing will suggest the evidence of such a benefit is sufficiently strong to warrant use by men lucky enough not to be diabetic.
Dale

 
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