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Old 12-22-2010, 04:21 AM   #1
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Genetic link between Bladder and Prostate cancer?

Hi,

I'm new to all this, not diagnosed with PC yet, but have had urinary problems for a while, and have been on Tamsulosin for 4 months with only slight improvement.
I saw my specialist earlier this week, and had another PSA.
PSA as follows:-
March 2005 = 0,67
August 2010 = 3.26 - Urine retention 327ml
December 2010 = 4.77 - Urine retention 321ml

Original 'trigger' to see a doctor was blood in my sperm, urinary frequency, hesitation and dribbling secondary at the time.

Next step is a TRUS Biopsy in January.

Now to the question:-

My father was diagnosed with bladder cancer about 5 years ago, his treatments have been removing the cysts trans-urethally, and a big course of Radiotherapy. He has also had two courses in intravescular (I think that is correct) Mytomycin chemo. He is 89, I am 59.

Is there any genetic link which make me more likely to have PC due to my father having BC?? My bladder is clear (had a cystoscopy in September).

Any feedback welcome.

I might be back in January if the biopsy is positive.

Sorry if this is in the wrong place.

 
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Old 12-22-2010, 09:21 AM   #2
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Re: Genetic link between Bladder and Prostate cancer?

Hi Erdinger,

You may be in a certain risk for bladder cancer (BC) as it runs in family members. But the prostate cancer (PC) is not related to BC. It should be a concern if your father have/had PC.

Only the biopsy will rule cancer, but the symptoms you describe are typical of benign prostatic hyperplasia (BPH) and bacterial prostatitis. Hematospermia (blood in sperm) is a symptom that could indicate PC or it could be caused by a bladder or urethra infection, if pain or fever is present.
The Tamsulosin is a medication for BPH used to relax the tightening of muscles compressing the urethra and therefore obstructing the flow of urine, but if your case is prostatitis you should take an antimicrobial medication to combat any inflammation.
The increase of PSA to 4.77 in just 6-month could be caused by an infection.
Have your doctor ever suggested infection? Or has he performed a digital rectal examination (DRE)?
You could try a dose of antibiotics before embarking on a biopsy to ascertain the facts.

For detailed information regarding side effects, etc., of BHP and prostatitis just use a net engine and type its name. I hope this info will be of some help to you.
Welcome to the board.

Have a good Christmas
Baptista

 
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Old 12-23-2010, 02:02 AM   #3
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Re: Genetic link between Bladder and Prostate cancer?

Thanks for the reply.

I should have mentioned that the first course of treatment given was to remove any infection, I then had urine analysis for infection that was negative.

The Tamsulosin has some effect on the symptoms, but they seem to be getting worse again.

Infection has been ruled out.

The consultant is considering a TURP to 'bore out' the prostate, but wants the biopsy before deciding. He also does not want me to take Finasteride at present due to the effect it has on PSA.

 
Old 12-23-2010, 03:50 AM   #4
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Re: Genetic link between Bladder and Prostate cancer?

Quote:
Originally Posted by erdinger View Post
Thanks for the reply.

I should have mentioned that the first course of treatment given was to remove any infection, I then had urine analysis for infection that was negative.

The Tamsulosin has some effect on the symptoms, but they seem to be getting worse again.

Infection has been ruled out.

The consultant is considering a TURP to 'bore out' the prostate, but wants the biopsy before deciding. He also does not want me to take Finasteride at present due to the effect it has on PSA.
In my opinon your doctor is doing the right think. He wants to use a realistic PSA in any future decision. Biopsy will give you peace of mind on the matter.
I wish you a good conclusion to your worries.
Take care
Baptista

 
Old 02-05-2011, 09:12 AM   #5
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Re: Genetic link between Bladder and Prostate cancer?



FINASTERIDE USE FOR A BPH PATIENT, AND PROSTATE CANCER

Hi erdinger,

I just got to your post, and thought I would add a few thoughts and a different point of view on finasteride use. I hope you are still monitoring replies. You wrote:


Quote:
Originally Posted by erdinger View Post
Thanks for the reply. [you to Baptista]

I should have mentioned that the first course of treatment given was to remove any infection, I then had urine analysis for infection that was negative.

The Tamsulosin has some effect on the symptoms, but they seem to be getting worse again.

Infection has been ruled out.
I'm a layman with no enrolled medical education, but I was drafted as a student of this disease about eleven years ago. From what I've heard and read, it is not really possible to fully rule out an infection unless you get a clear link with the cause. There are a lot of bacteria that can cause trouble, and it is often hard or impossible to find the right antibiotic that will kill the responsible bacterium. Urine analysis helps, but, if negative, I don't think it is definitive of no infection. Some infections are stealthy, and they wax and wane.

Quote:
The consultant is considering a TURP to 'bore out' the prostate, but wants the biopsy before deciding. He also does not want me to take Finasteride at present due to the effect it has on PSA.
I've been on finasteride (previously under the brand name, Proscar, before it went generic) continuously for more than ten years now. It's the light-weight but still important leg of my triple hormonal blockade therapy, which has been my sole therapy for prostate cancer. I've followed research and opinion about finasteride closely.

Here's the deal: it should lower PSA by approximately 50% within six months of starting the drug. That's what the doctor is concerned about because the PSA will be "artificially" lower than it otherwise would be, therefore likely falling below trigger thresholds for concern about possible prostate cancer. However, pioneering doctors have turned that into an advantage for monitoring for possible prostate cancer: if the PSA drops by 50% or more, or perhaps just a bit less, by the six month point, that is a good indication (though not certain) that the patient does not have prostate cancer. On the other hand, if the drop is substantially less than 50%, then that's a sign of increased likelihood of prostate cancer. The experts respond in that case by increasing monitoring, such as with PSA tests and DREs every three months instead of six months or yearly, and perhaps with "free PSA" tests, PCA3 tests, or other appropriate tests. The level and trend in PSA for a patient on finasteride are even more useful as indicators of prostate cancer than they are for patients not on finasteride (or Avodart). In effect, these drugs sharply reduce or eliminate the "noise" in the PSA signal that is due to benign enlargement. The monitoring doctor simply doubles the PSA value to compare it to guideline values, and an upward trend is more likely prostate cancer than an upward trend for a patient not on finasteride, especially if that trend is "exponential". Many doctors do not understand these key points. That's understandable as this is kind of a specialty area. It's too bad, because this knowledge would lead to better care for us patients.

Moreover, finasteride and Avodart have been proven to prevent (or eliminate) some low "Gleason grade" prostate cancer, meaning cancer that is less aggressive, the kind that may never need treatment over a man's lifetime under a diligent active surveillance program. However, that advantage is controversial; some doctors and researchers feel it will reduce the number of biopsies that could catch the high grade cancers that are not affected, apparently, by finasteride or Avodart.

In short, finasteride could give you a triple benefit: relief from BPH, better screening for possible prostate cancer, and prevention of low-grade prostate cancer.

I can give you some leads to supporting research if you would like.

Take care,

Jim

 
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