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Old 01-06-2011, 11:48 PM   #1
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Post Supplements that may help with Radiation

This table shows commonly available (except statins, which are by Rx in the US) supplements that have been shown in research to (1) protect healthy tissue from radiation, particularly if it protects the endothelial tissue of the bladder and urethra and enteric tissue, and if it prevents fibrosis; and (2) sensitize cancerous tissue to radiation, or prevents cancers from protecting themselves. I have the research studies to back this up, if you are interested.

Remember that radiation kills cancer cells because of oxidation reactions, so that many popular "anti-oxidants" may work against what radiation is trying to achieve. The last thing we want to do is protect the cancer cells from the radiation. Always let your RO know what you are taking.

Also, there are many known, more powerful radioprotectants (e.g., Amifostine) and radiosensitizers (e.g., Flagyl) that are far from the category of supplements and not included here.

--------------------------Radioprotective ------------Radiosensitizes
---------------------------------Effects-------------------------------

Exercise-------------Prevents fatigue &----------------through increased
-------------------------Rectal Symptoms---------------oxygenation

Statins----------------Protects endothelial tissue----------PCa cells
--------------------------Prevents fibrosis
--------------------------Prevents thrombopenia
--------------------------Protects intestines

Omega-3s/Fish Oil---Protects endothelial,----------Lung, Colorectal,
--------------------------mucosal & epidermal cells----Head & Neck Cancers

Curcumin/Turmeric---Protects endothelial cells----PCa, Lung Cancer
----------------------------Prevents fibrosis--------------Neuroblastoma

Soy Isoflavones-------Protects endothelial cells --------PCa cells
--------------------------Protects blood & bone marrow
--------------------------Prevents fibrosis

COX-2 Inhibitors:-----Prevents urinary retention--------PCa cells
Celebrex
Ibuprofen
Naprosyn

Quercetin-------------Leukocytes----------------------reduces PCa
---------------------------Mitochondria -------------------radioprotective
-------------------------------------------------------------heat-shock proteins

 
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Old 01-07-2011, 08:39 AM   #2
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Re: Supplements that may help with Radiation

Thank you, Allen. Unfortunately, now, I'm really confused and these supplements are getting expensive and I've been trying so hard to get him what's best for his situation. With all of Irv's doctor's appointments, he is unable to put in a full time work load...so no money. He's self employed so...no drug plan. All of this is getting expensive and the emotional toll that this illness is taking on us is starting to show at different times.

So, now Irv's taking a multivitamin for men, green tea extract, pomegranate pills, wild salmon oil, Vitamin D and Lycopene.

The oncologist doesn't want to consider a Zoladex shot until he gets the result back from the bone and CT scans. The bone scan was already done yesterday but he doesn't have the CT scan scheduled until January 20th. If Irv gets the shot, it won't be until the beginning of February.

So, now I'm wondering....Can Irv take all those vitamins and antioxidants in the meantime and what should he take and what shouldn't he take based on that chart and when. Excuse me, I'm just really overwhelmed, confused and just a little tired. Right now, my main goal is to keep my emotional state in check for Irv and to be there for him all the way. Last night was a bad night for him. The battery light started flashing on the van...and he just paid over $500 on it a couple of weeks ago to get it fixed. Yes, the van is getting tired too, but now isn't the time to get a new van. With all of his appointments and loss of income, and sitting in traffic getting to and from appointments and the run around when trying to make appointments or communicate with doctors....and the lack of sleep and exhaustion from all of this...Well, I guess he reached his breaking point last night. He's doing better today, but I just don't know how bad this is going to get before we can feel like life is a little more tolerable than it is now.

I know this is primarily a board with men.....so thank you for accepting me here and being so helpful....and thanks for giving me a place to vent with people who've been there and done that. This is just getting really difficult.

Rhonda

Last edited by honda50; 01-07-2011 at 10:56 PM.

 
Old 01-07-2011, 03:12 PM   #3
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Re: Supplements that may help with Radiation

Hi Rhonda,

I'll add some comments to your post. Allen's table looks good to me.


Quote:
Originally Posted by srhonda61 View Post
Thank you, Allen. Unfortunately, now, I'm really confused and these supplements are getting expensive and I've been trying so hard to get him what's best for his situation. With all of Irv's doctor's appointments, he is unable to put in a full time work load...so no money. He's self employed so...no drug plan. All of this is getting expensive and the emotional toll that this illness is taking on us is starting to show at different times.

[I moved this up from below.]

Excuse me, I'm just really overwhelmed, confused and just a little tired. Right now, my main goal is to keep my emotional state in check for Irv and to be there for him all the way. Last night was a bad night for him. The battery light started flashing on the van...and he just paid over $500 on it a couple of weeks ago to get it fixed. Yes, the van is getting tired too, but now isn't the time to get a new van. With all of his appointments and loss of income, and sitting in traffic getting to and from appointments and the run around when trying to make appointments or communicate with doctors....and the lack of sleep and exhaustion from all of this...Well, I guess he reached his breaking point last night. He's doing better today, but I just don't know how bad this is going to get before we can feel like life is a little more tolerable than it is now.
Many of us have probably hit that low point at some time in dealing with the disease, the point where it gets overwhelming and any good thing seems impossible. For me it was about two weeks after the diagnosis. I was trying to move a big job to the next stage, which would enable others to respond, and the next day my wife and I planned to leave by plane for a Christmas reunion with our sons, with preparations also adding stress while I tried to keep medical appointments and learn more about the disease, the weather not cooperating. Well, my computer crashed, and that added in to other mishaps. That's the lowest I've felt for years. Fortunately a co-worker came to my rescue, and we did make the get away for our vacation. Some days a little time and a little help from a friend can make an important difference!

Quote:
So, now Irv's taking a multivitamin for men, green tea extract, pomegranate pills, wild salmon oil, Vitamin D and Lycopene.
Those look good to me except for the multivitamin. The main problem with multis is that most of them have a lot of vitamin A and it's a kind of vitamin A that is not good for prostate cancer patients. However, I'm not a doctor of course, and the multi may be good overall considering other health concerns.

Quote:
The oncologist doesn't want to consider a Zoladex shot until he gets the result back from the bone and CT scans. The bone scan was already done yesterday but he doesn't have the bone scan scheduled until January 20th. If Irv gets the shot, it won't be until the beginning of February.
That should still be timely.

Quote:
So, now I'm wondering....Can Irv take all those vitamins and antioxidants in the meantime and what should he take and what shouldn't he take based on that chart and when.
Allen's table is basically about supplements and radiation, not hormonal blockade or distant preparation for radiation. My impression is that the antioxidants can be taken until near the time of radiation and again after radiation has done its work (may take months with seeds, which give off the radiation gradually).


Quote:
I know this is primarily a board with men.....so thank you for accepting me here and being so helpful....and thanks for giving me a place to vent with people who've been there and done that. This is just getting really difficult.

Rhonda
So often we guys are very dependent on our wives to help us with medical care, and they do a great job. We get a lot of women on this board. I'm glad the board is a place you can vent. It's often hard or impossible to do that with a loved one.

Take care,

Jim

 
Old 01-07-2011, 05:01 PM   #4
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Re: Supplements that may help with Radiation

Quote:
Originally Posted by IADT3since2000 View Post
Those look good to me except for the multivitamin. The main problem with multis is that most of them have a lot of vitamin A and it's a kind of vitamin A that is not good for prostate cancer patients. However, I'm not a doctor of course, and the multi may be good overall considering other health concerns.
I think multis are pretty much a waste of money. Nutrition should come from food, not pills, as I've said before. However, most multis will not harm at all, imho. A form of Vitamin A, cis-retinoic acid, actually seems to help radiosensitization when combined with interferon.


Quote:
Originally Posted by IADT3since2000 View Post
Allen's table is basically about supplements and radiation, not hormonal blockade or distant preparation for radiation. My impression is that the antioxidants can be taken until near the time of radiation and again after radiation has done its work (may take months with seeds, which give off the radiation gradually).

I used a strategy of loading up for a few months prior to radiation, as was used in some of the studies I found. Certain of those supplements accumulate only very slowly in the prostate. Curcumin, for example, is notoriously difficult to accumulate to the point that it will do any good, which is why chemists are working on alterations of the molecule that increase bioavailability.

Radiation causes damage to the DNA of the cancer cell that may cause it to go "underground" for months after the radiation source is gone, whereas the free radicals generated by the radiation can persist for a long time afterwards. You want them to be around when the cell comes out of hiding, so to speak. So it may not be a good idea to take "anti-oxidants" for a while afterwards. A recent study found that cancer cells that recovered from radiation, did so in about 2 months after treatment on the average. Based on this, I avoided anything beyond nutritive sources of C, E, selenium, and glutathione. Perhaps I am over-cautious, but I did not want to risk messing up the radiation, unless there was at least some research that told me it might be beneficial.

By the way, I run EVERYTHING I take by my R.O. He was the one who prescribed low-dose statins for me. Hint: I always ask for scrips for the highest dose pills possible and split the pills myself. This saves lots of money.

- Allen

Last edited by Tall Allen; 01-07-2011 at 05:03 PM. Reason: added quote

 
Old 01-07-2011, 11:05 PM   #5
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Re: Supplements that may help with Radiation

Thanks, Jim and Allen. So, I've gotta say that this nutritional supplement thing is a learning curve. I guess I'll check the Vitamin A content in the multivitamin and if we decide he shouldn't take it, then I'll pass them onto my sons.

So, in the selection of things that I've given to Irv, is there something else that I've missed? I'm figuring that he'll take these things up until we see the radiation oncologist again and I'll run it by him and probably Irv will stop taking them during radiation, if that should happen.

So, I guess I'm on the right track with this. Please tell me what else he needs to take that would be really important at this time.

Thanks.
Rhonda

 
Old 01-08-2011, 12:04 AM   #6
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Re: Supplements that may help with Radiation

If you're talking to me, that's not at all what I said.

 
Old 01-08-2011, 12:40 AM   #7
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Re: Supplements that may help with Radiation

Allen, I'm not sure what you're referring to. I think I've understood that Vitamin A may or may not be good for prostate cancer depending on which form it is.

Did I say something incorrect? I wouldn't be surprised. As I said, this is overwhelming at times...and a pretty big learning curve.

Please clear up my misunderstanding.

 
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