Hello everybody. I have been off ADT for 7 months now after being on for 5 years. My PSA is still <0.01 which makes me very happy. I have an excellent lipid profile with HDL of 66 LDL of 40 TRI of 30 total cholesterol of 112. But since being off ADT my T has not recovered. My Question is should I be concerned? I do take Lipitor and Celebrex. Is there a relationship between T and cholesterol? Thanks for all the help.
It's good to have another intermittent ADT guy on the board; I've been on and off therapy for eleven years now. I'll insert comments in green.
Originally Posted by 3YearSurvivior
Hello everybody. I have been off ADT for 7 months now after being on for 5 years. My PSA is still <0.01 which makes me very happy.
I have an excellent lipid profile with HDL of 66 LDL of 40 TRI of 30 total cholesterol of 112.
But since being off ADT my T has not recovered. My Question is should I be concerned?
I'm not a doctor but have come to learn a lot about IADT. It's very likely, based on what I've heard and read from experts, that ADT continuously for five years has permanently shut down testicular production of testosterone. That apparently happens fairly often after just two years in men aged around 70 or older, but it takes longer in younger men. (I was on ADT for 31 months straight for my first cycle and was able to recover T to over 1,000.) The good side of your situation is that you may not need either an LHRH-agonist type drug, such as Lupron or Zoladex, or castration, to maintain that low testosterone and consequently a low PSA. The challenging side of it is that you may need testosterone supplementation if you want to recover to a normal level. Such supplementation may or may not be wise, depending on the circumstances of your case.
I do take Lipitor and Celebrex. Is there a relationship between T and cholesterol? Thanks for all the help.
I'm not sure about that. Cholesterol is a precursor element of PSA, but I do not recall that it is related to testosterone. However, my hunch is that your enviably low cholesterol is not causing your low testosterone.
I hope this helps. Please come back with any further concerns or follow-up to this post.
Testosterone is produced from cholesterol, therefore, low cholesterol can influence the level of testosterone in your body. Here is an article that may help you understanding hoe testosterone is produced and the relationship between both.
“Testosterone Production in the Body
This important hormone is produced mainly in the testes in males (more than 95 percent) and in the ovaries in females; however, small amounts are made in the outer layer of the adrenal glands in both sexes. The process that carefully regulates the amount and timing of testosterone production is complex and begins in the brain. When a man feels aroused or successful, the cerebral cortex, the most sophisticated area of the brain, sends a signal to another part of the brain called the hypothalamus to stimulate the production of testosterone. The hypothalamus is an area at the base of the brain that regulates much of the body's hormonal activity. It does this by sending chemical signals to the pituitary gland, a cherry-sized organ that produces a wide variety of hormones involved in the regulation of growth, thyroid function, blood pressure, pregnancy, birth and other critical body functions.
To stimulate testosterone production, the hypothalamus releases a substance to the pituitary gland called gonadotropin-releasing hormone (GnRH). This hormone, in turn, causes the gland to produce two other hormones, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), collectively known as gonadotropins. LH is released into the bloodstream where it travels to the male testes and triggers the production of testosterone from cholesterol. If this process continues until the testosterone level becomes too high, the pituitary slows the release of LH so production slows down. FSH is similarly involved in the increase and decrease in sperm production.
When LH reaches the testes, it influences activity in the Leydig cells, which are where cholesterol is gradually changed into a series of compounds until it becomes testosterone. When the small but vital amount of testosterone produced is released into the bloodstream, it is mostly bound to a special "carrier" compound called sex hormone binding globulin or SHBG. SHBG, which is produced by the liver, plays an important role in regulating the amount of "free" testosterone circulating in the body at any one time. The more SHBG there is the less unbound, active testosterone is able to move from the blood stream into cells where it is needed. As SHBG levels rise and fall, so do free testosterone levels, except in reverse.
With such a complex chain of events leading to a normal testosterone level, many problems or interruptions along the process can lead to sub-normal or low testosterone levels in men at any age. If there are diseases or negative conditions involving the male testes, hypothalamus, pituitary gland or genetic material, the resulting state is called hypogonadism.”
Hey Jim thanks for your reply. I am sure we will talk again, I have read your story and appreciate your knowledge and willingness to share. We have very similar stories, High base PSA and GS. Thanks again
Hi Baptisa, thanks for the info. I have read the story in Dr Strums book hence the question. I am doing well and plan to continue to stay ahead of it being pro-active rather then re-active. Thanks for all your help.
Last edited by 3YearSurvivior; 01-13-2011 at 05:55 PM.