It appears you have not yet Signed Up with our community. To Sign Up for free, please click here....



Cancer: Prostate Message Board
Post New Thread   Closed Thread
LinkBack Thread Tools
Old 04-08-2011, 04:13 PM   #1
Junior Member
(male)
 
Join Date: Jan 2011
Location: Wichita, KS
Posts: 15
VicRider HB User
U.K. develops new urine test for PCa

I've been doing some reading about PSA levels, PCa, and the like, and I found an article that suggests scientists in the U.K. have developed a more reliable test for detecting the presence of PCa versus using a regular PSA test.

According to the article, this new simple urine test looks for the presence of a protein called EN2, which in adult men is only made by cancerous prostate cells.

Supposedly, this new test has a higher reliability rate for detecting PCA versus using a standard PSA test (66% vs. 40% respectively). In addition, the the "false positive" rate for the test was only four per cent.

The test is still being studied, including detecting the presence of aggressive vs. non-aggresive cancers.

Has anyone else read up on this? Your thoughts?
__________________
JohnC - Wichita, KS

Last edited by VicRider; 04-08-2011 at 04:14 PM.

 
The Following User Says Thank You to VicRider For This Useful Post:
IADT3since2000 (04-09-2011)
Old 04-09-2011, 12:21 PM   #2
Senior Veteran
(male)
 
Join Date: Nov 2007
Location: Annandale, VA, USA
Posts: 1,730
Blog Entries: 3
IADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB User
Re: U.K. develops new urine test for PCa

Hi John,

Thanks for pointing out this promising new potential test. I found the abstract for this recently published report, which has this citation:

Clin Cancer Res. 2011 Mar 1;17(5):1090-8. Epub 2011 Mar 1. Engrailed-2 (EN2): A Tumor Specific Urinary Biomarker for the Early Diagnosis of Prostate Cancer.
Morgan R, Boxall A, Bhatt A, Bailey M, Hindley R, Langley S, Whitaker HC, Neal DE, Ismail M, Whitaker H, Annels N, Michael A, Pandha H.

Authors' Affiliations:Postgraduate Medical School, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom; St. George's, University of London, London, United Kingdom; Royal Surrey County Hospital, Guildford, United Kingdom; Uro-Oncology Research Group, CRUK Cambridge Research Institute, Cambridge, UK; Basingstoke Hospital, Basingstoke, United Kingdom.

I'll add some comments in green.


[QUOTE=VicRider;4726117]I've been doing some reading about PSA levels, PCa, and the like, and I found an article that suggests scientists in the U.K. have developed a more reliable test for detecting the presence of PCa versus using a regular PSA test.[QUOTE]

Based just on the abstract, which is probably a firm basis, the test is not ready for clinical use yet except in clinical trials to determine its effectiveness. However, I believe it is possible to do such trials quickly - it's not like we have to wait for years to check progression of the cancer or survival, we just need to make sure the test results correspond to the actual presence or absence of prostate cancer.

Quote:
According to the article, this new simple urine test looks for the presence of a protein called EN2, which in adult men is only made by cancerous prostate cells.
What I especially like about this test is that it is a simple urine test - just peeing into a container as far as the patient is concerned. We already have a urine test for the PCA3 gene, and that test provides some useful information in predicting the presence or absence of prostate cancer, but the PCA3 tests require a prior "attentive" DRE, basically a brief prostate massage by a medical professional, prior to giving the urine sample.

Quote:
Supposedly, this new test has a higher reliability rate for detecting PCA versus using a standard PSA test (66% vs. 40% respectively). In addition, the the "false positive" rate for the test was only four per cent.
Here is a brief excerpt from the abstract: " ... A number of key limitations with prostate specific antigen (PSA), currently the standard detection test, has justified evaluation of new biomarkers. We have assessed the diagnostic potential of Engrailed-2 (EN2) protein... expressed in PC cell lines and secreted into the urine by PC in men.... RESULTS: EN2 was expressed and secreted by PC cell lines and PC tissue but not by normal prostate tissue or stroma [meaning muscle-like connective tissue for the prostate, in this case]. The presence of EN2 in urine was highly predictive of PC, with a sensitivity of 66% and a specificity of 88.2%, without requirement for DRE. There was no correlation with PSA levels. These results were confirmed independently by a second academic center.... CONCLUSIONS: Urinary EN2 is a highly specific and sensitive candidate biomarker of prostate cancer. A larger multicenter study to further evaluate the diagnostic potential of EN2 is justified. Clin Cancer Res; 17(5); 1090-8. ©2011 AACR. PMID: 21364037

That 66% sensitivity means that it is going to pick up prostate cancer if it is there about two thirds of the time. Actually, that is impressive - a lot better than PSA alone at 40%, though obviously not perfect. What is highly impressive is the specificity at 88.2%; that means it is highly unlikely to give a result that falsely indicates that prostate cancer is there - a false report in every one of twelve cases. That is far, far superior to PSA, which is really a hyper-alert sentry for a variety of things that can be wrong with the prostate, mainly benign enlargement, infection or inflammation, or, of course, prostate cancer.

My recollection is that the sensitivity and specificity are also both better than those figures for PCA3 tests; I'm sure that the sensitivity is a lot better, as it appears to take a fair amount of cancer to trigger a positive PCA3 result. PCA3 tests are quite specific, but that 88.2% specificity is going to be hard to beat! I hope they will be able to maintain figures like this in clinical trials and ultimately in clinical practice.


Quote:
The test is still being studied, including detecting the presence of aggressive vs. non-aggresive cancers.

Has anyone else read up on this? Your thoughts?


I was not aware of this before your post, though those of us keeping an eye on emerging new tests have seen a number of promising potential tests. I'll see if I can find out more about it.

Thanks again.

Jim

 
Sponsors Lightbulb
   
Old 04-09-2011, 01:06 PM   #3
Senior Veteran
(male)
 
Join Date: Nov 2007
Location: Annandale, VA, USA
Posts: 1,730
Blog Entries: 3
IADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB UserIADT3since2000 HB User
Re: U.K. develops new urine test for PCa

Hi again John. I've checked some other sources and learned there has been quite a bit of study of EN2, but it appears to be just coming to the front of the stage as far as potential clinical use.

I found it was not covered at the recent IMPaCT conference I attended (US Dept. of Defense managed prostate cancer research designed to be high risk/high reward). It was also not covered in the annual meeting of the American Association of Cancer Research (which actually has a large international membership) that was held this April. However, the article was published in one of the AACR's journals.

Take care,

Jim

 
Closed Thread

Similar Threads
Thread Thread Starter Board Replies Last Post
PCA3 Plus Test - Questions broderbund Cancer: Prostate 1 08-09-2010 09:23 PM
Should we seek a 3rd opinion for how to proceed after a PSA test? nadamlie Cancer: Prostate 5 06-19-2010 08:33 AM
Ready for vacation from triple blockade - mostly good test results, but a concern too IADT3since2000 Cancer: Prostate 6 04-30-2010 02:27 PM
False alarms with ultrasensitive PSA test? laughagain Cancer: Prostate 4 10-16-2009 02:19 PM
wait six months for next psa test? clem752 Cancer: Prostate 1 10-15-2009 10:08 AM




Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is Off
HTML code is Off
Trackbacks are Off
Pingbacks are Off
Refbacks are Off




Join Our Newsletter

Stay healthy through tips curated by our health experts.

Whoops,

There was a problem adding your email Try again

Thank You

Your email has been added




Top 10 Drugs Discussed on this Board.
(Go to DrugTalk.com for complete list)
Casodex
Cialis
Cipro
Flomax
Levaquin
  Levitra
Morphine
Proscar
Tylenol
Viagra




TOP THANKED CONTRIBUTORS



Tall Allen (174), IADT3since2000 (148), Baptista (97), Gleason9 (28), harpman (27), Johnt1 (22), honda50 (9), tumbleweed (6), flyfisher37 (6), kcon (5)

Site Wide Totals

teteri66 (1180), MSJayhawk (1004), Apollo123 (904), Titchou (847), janewhite1 (823), Gabriel (759), ladybud (754), midwest1 (668), sammy64 (668), BlueSkies14 (610)



All times are GMT -7. The time now is 05:00 PM.



Site owned and operated by HealthBoards.comô
Terms of Use © 1998-2014 HealthBoards.comô All rights reserved.
Do not copy or redistribute in any form!