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Cancer: Prostate Message Board
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Old 11-21-2011, 07:37 PM   #1
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High PSA Biopsy Negative

I received my biopsy results yesterday and no cancer was detected but I still wonder if they just didn't find it first time around. (10 samples taken)

They have not detected any infection so what is it?

My PSA was around 9 a year ago and jumped to 24 a few weeks ago.
At another hospital about a week later the PSA was 18.

Digital examination by two different doctors showed no abnormalities.

Symptoms trouble urinating and getting up during the night so I've be given Harnal for benign prostatic hyper trophy. age 53

Doctor said you are "all clear" see you in three months for a PSA test.

What steps would you take in my position as I'm still concerned? Thank you to all.

 
Old 11-21-2011, 08:35 PM   #2
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Re: High PSA Biopsy Negative

Cact,
Bph does not usually cause a psa of 24 and a high psa is abnormal and must be investigated and all causes eliminated. Unfortunately the vast majority of doctors just don't know how to do this. It took me 10 years to find this out as my psa went from 4 to 40 with 13 biopsies showing negative. Your biopsy report should have the size of your prostate in cc. multiply the size by .1 and you will get the psa caused by bph. Anything in excess of that must be explained.
First I would take a course of antibiotics, Cipro or Bactrum and if infection is the cause your psa should drop. If psa does not drop you must assume that the psa is due to PC and there are certain actions that you can take.
A tumor that generates a psa of 24 must be fairly large and easily picked up on a biopsy if in the peripheril zone. Transition zone tumors or tumors in the anterior are harder to identify by standard biopsy and a high psa is indicative of a transition zone tumor, and this must be the first place to look. A color dopppler ultrasound guided biopsy or a saturation biopsy concentrating on the anterior would be the next step.
The cause of high psa are:
1. infection
2. metastitis to the lymphnodes
3. transition zone tumor
4. PSA leak (extremely rare)
Good luck and make your doctors explain the high psa; if they can't then find a doctor that has a lot of experience in Dxing pc.

 
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Old 11-22-2011, 01:45 AM   #3
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Re: High PSA Biopsy Negative

Because you're in Japan, this will probably be of no use to you, and I certainly can in no way vouch for the test's accuracy, but a Canadian company called Mitomics has a new test called the Prostate Core Mitomics Test. They claim their test, using your biopsy tissue samples, can identify false negatives. They say that cancer anywhere in the prostate causes a "field effect" that changes the mitochondrial DNA slightly everywhere in the prostate. So even if the biopsy cores missed the tissue where cancerous cell alteration occurred, they can still tell from them if the prostate had cancer somewhere close by.

This appears to be legitimate, and is very interesting, if true.

- Allen

 
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Old 11-22-2011, 03:52 AM   #4
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Re: High PSA Biopsy Negative

Thank you very much Johnt1 I appreciate your detailed answer. So many of you have helped us newbies through the process. Cheers

 
Old 11-22-2011, 03:55 AM   #5
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Re: High PSA Biopsy Negative

Actually I will be visiting Canada in January so this information is very helpful.
Thanks Tall Allen

 
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