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Old 03-11-2012, 10:29 PM   #1
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Testosterone rise during triple blockade androgen deprivation therapy???

I'm having a bit of a worrisome moment as something suddenly hit me....

Near the beginning of Irv's hormone therapy, his testosterone was .6 nmol/l. At the last check, at the end of his first year on hormone therapy, just as he was coming off, his testosterone measured at 1 nmol/l.

I began thinking, and wondering whether this might indicate that the cancer is already becoming hormone refractory and that the cancer is already starting to produce it's own testosterone. Is this a crazy thought?

Irv's PSA is still undetectable at <.02, but isn't it possible that it could have actually jumped quite a bit within that undectable zone (ie from .001 to .009 for example)?

I really hope I get some input on this soon because it's suddenly caused me to freak out a little inside.

Rhonda

Last edited by honda50; 03-11-2012 at 10:30 PM.

 
Old 03-11-2012, 10:46 PM   #2
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Re: Testosterone rise during triple blockade androgen deprivation therapy???

I feel a little better now as I've found out that Irv's testosterone is still at a level which would make him safe from hormone refractory cancer for awhile (from what I've read, as long as the testosterone is <32 ng/dl and Irv's would be about 28 ng/dl)...Although, it is frighteningly close...Yes, sometimes I start to panic a little...I have my moments....A lot has to do with that DHT concern.

The DHT concern made me start to wonder about Irv's increased testosterone. I read that sometimes testosterone goes up towards the end of the period that the injection was given. Although, as far as I remember, Irv's testosterone was checked at the same time with each injection....so it's still a little puzzling.

I also read that it might be because there is the presence of higher than expected levels of adrenal androgens. We are waiting for the blood test result back for Irv's DHEA-S and androstenedione because if they're high, that would be a good indicator of this. I'm not sure what we'd do that were the case.

It could also be because the Zoladex didn't get absorbed well into Irv's body this time....but I doubt that because his PSA was undetectable and he had no knots or bumps below the surface where he was injected which is what supposedly happens if the drug isn't properly getting into the system.

So, the mystery remains....I guess we'll just have to wait and see what Dr Myers thinks of this.

Rhonda

Last edited by honda50; 03-12-2012 at 02:12 PM. Reason: copying & pasting from other sources is never permitted.

 
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Old 03-11-2012, 11:27 PM   #3
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Re: Testosterone rise during triple blockade androgen deprivation therapy???

No need to worry for another reason. Hormone refractory or castrate resistant PC is not reflected in rising serum testosterone levels. Hormone refractory PC means that the androgen receptors of the PC cells are activated in spite of the serum testosterone being at castrate levels.Serum testosterone is mostly generated in the testes (plus a little in the adrenal glands). The testosterone generated intracellularly in the PC cells does not show up in the serum. There's no way to measure intracellular T short of a biopsy of the tumor. If castrate resistance should happen, you would know because PSA would rise in spite of the sources of of serum testosterone being shut off.

- Allen

 
Old 03-11-2012, 11:48 PM   #4
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Re: Testosterone rise during triple blockade androgen deprivation therapy???

Thanks for setting me straight, Allen. I guess I'm at a whole new level of trying to understand this disease. I'm really getting confused with this whole business of Testosterone and DHT....Some of it just doesn't seem to be making much sense to me these days.

Irv gets his first PSA check on Wednesday, since coming off the hormone therapy. We're hoping for some good news so far.....

Rhonda

 
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