At your age I do not see anything alarming about the rise of 1.4 in a year, even though most of it was within the last three months. Your PSA can fluctuate naturally by that much. I really like the fact that your biopsy came up negative last year.
Have you had a Free PSA done? If not I would ask your Urologist to order this blood test as well because it can give you some more info to go by. Has your Urologist ruled out BPH?
If you have already gone through a a course of antibiotics for BPH then I would assume that if your Free PSA comes back abnormal, your Urologist will probably suggest another biopsy.
Good luck and keep in touch!
Last edited by thepineman; 05-15-2012 at 02:29 AM.
and my approximate PSA density is 6.4/57=0.11, which I assume it's a good sign, but how significant does this number suggest?
A density of 0.11 is a good number, indicating that normal PSA tissue (though from an enlarged prostate) could well be accounting for that PSA of 6.4. One favorable criterion for active surveillance for men with diagnosed prostate cancer is a PSA density of 0.15 or lower, and you are well below 0.15.
On the other hand, there are some research based rules of thumb for PSA produced by healthy cells. One is to take the prostate volume in cc and multiply by 0.066, which would yield 57 X .066 = 3.76 for you, suggesting some unexplained PSA. Another is to take one tenth of the volume, which would be 57 rounded to a projected PSA of 6, fairly close to your recent PSA.
I too think a PCA3 test could help. Getting PSAs every few months and watching for a trend would also be wise.
Do you know about nutrition and lifestyle tactics to reduce the risk of prostate cancer? Do you know about avoiding activities that might influence the PSA in the day or two before the blood is drawn?