Re: Anybody thinking about Immunotherapy as a treatment?
That's because there's not yet much available to discuss. The only FDA-approved vaccine for PC is Provenge, but it has only been approved for mCRPC so far. Yervoy is in clinical trials but is theoretically available off-label (it's been approved for melanoma). I say theoretically because these are hella expensive (about $120,000 for 4 Provenge treatments, if I remember right) and I doubt insurance would cover it off-label. Some of these have had cases of life-threatening side effects. I think Provenge has a 4 month survival advantage on the average. The 4 month figure is a little deceptive because it has no effect at all in some men and can add years in others.
There are a few other vaccines and immune boosters like Prostvac-VF and GVAX that are in tests for mCRPC. They are also testing combos of these, e.g., prostvac or GVAX with Yervoy. Phase 2 trials are encouraging. These kinds of things are almost always tested to prove a survival advantage for mCRPC first, and often only after chemo failure. It takes a long time to show a survival advantage earlier in the process so such trials take a long time.
I've seen one trial of immunostimulants GM-STF and pTVG-HP plasmid DNA vaccine in men with rising PSA after definitive therapy. Clinicaltrials.gov lists all FDA-registered clinical trials. If you enter "prostate cancer" and "vaccines" or "immune boosters" you can find out what they are testing, what the inclusion criteria are, which are recruiting, and where the tests are.