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Old 06-08-2013, 08:18 AM   #1
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Lupron and male breast swelling

Shortly after starting a series of Lupron injections every three months, my breasts have swollen to a size that may be found in a twelve or thirteen year old female. The injections were stopped after bringing my PSA down from 7.5 to .07 a year ago. I am due for a PSA reading next month. and remain wary that I may have to revert to the injections if it starts to climb again (I went through external radiation treatments 1o years ago and was in remission for eight years).

While I don' look forward to the hot flashes and sweats, I mostly dread continued swelling which can't be hidden by loose garments and make me appear as a transsexual in progress. Unfortunately, it wasn't until recently that I learned this could have been avoided with radiation to the area prior to hormone therapy.

When I questioned my urologist as to why I wasn't informed of this possible side effect and to avoid it from happening, he replied that no urologist will suggest prior radiation because of the risk of exposure and the small number of enlargement cases. I have been under his care for fifteen years and had confidence in his ability, but now less so. I am curious to know if anyone on this board had a similar experience or had been forewarned by their doctor.

 
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Old 06-08-2013, 09:40 AM   #2
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Re: Lupron and male breast swelling

I know 2 guys who had the radiation pre-treatment for this common occurrence. However, tamoxifen may work even better than radiation. In fact, some researchers found it worked much better:
http://www.ncbi.nlm.nih.gov/pubmed/22704706

Of course prevention would have been better, but there's still a chance to treat it. In the following study, they found that 20 mg daily tamoxifen worked well:
http://www.ncbi.nlm.nih.gov/pubmed/22502790

The downsides to tamoxifen are mainly the increased risk of thromboembolytic events, and the unknown long-term interaction with Lupron.

The other options include corticosteroids to break down the excess tissue or surgical removal. You might want to discuss these alternatives with a sympathetic doctor.

- Allen

 
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Old 06-08-2013, 10:10 AM   #3
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Re: Lupron and male breast swelling

Thanks, Alan. Your reply is timely, as I will be seeing my dermatologist next month.I have read several of your posts and am amazed at your font of knowledge. evidently you must have been in the medical field.

 
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Old 06-08-2013, 10:17 AM   #4
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Re: Lupron and male breast swelling

Sorry for the misspelling of your name,Allen.

 
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