RickGeorge

Hi All

This is my first post so bear with me.

My 4 month old daughter, Isabelle, was diagnosed with a rhabdomyosarcoma three weeks ago and started on the IVA chemotherapy regime (Ifosfamide, Vincristine, can't remember the third!)

The tumour started in the corner of her eye when she was two months old and had grown very aggressively (almost to the size of a golf ball) by the time she three and a half months old. It covered her eye so much that she could not open it.

She has had one dose of all three drugs at Great Ormond Street Hospital in London and two doses of Vincristine. She is back at the hospital this thursday for her second dose of all three IVA drugs.

Up until last Sunday (two weeks after commencing her chemotherapy) we could see a positive reduction in the size of her tumour, she could open her eye slightly which gave my wife and I a real sense of optimism.
However, since Sunday, the tumour seems to be possibly growing again (albeit not as quickly as it did before she was diagnosed)

My question is, "Is this normal?" Should the tumour decrease for two weeks and then start to increase again? Is this a bad sign that the chemotherapy regime is not working or should we expect it to reduce again once she has had her second three day dose in hospital.

If there is anyone with any thoughts, please reply

Many thanks
Rick George