Ice cool, I noticed a difference right away, with in the first few days of taking them.
You wouldn't believe how many drugs are made through animals, a lot of hormonal drugs are produced from them.
I know in some of the hormone replacement meds I used to take, they used the urine of a horse to produce the drug. I think the horse was pregnant and would produce an excess of hormone, or something. I went to a more natural type that had very little of this type of hormone in them.
So, in your case you may be stuck with adrenal fatigue if your body isn't responding to what your taking and you won't take a bovine adrenal support supplement.
The only exception to this is capsules marketed as veggie source which are not bovine.
Look up Vegetarian Adrenal