Plaquenil helped my fatigue for awhile. But if a medication like that works for you, you likely have an autoimmune disease your doctor is too dumb to diagnose. forgive, i'm on a rampage today.. Well, there is also medications like provigil to help keep you awake, typically for sleep disorders. The really good speed medications for ADHD like Adderall or Ritalin, they will prescribe this if you have a bad case of fatigue. I was on 90mg of adderall a day at one point, but what comes up must go down. Some people say it stops there fatigue, it did bring me some energy but I still stayed tired, and I crashed hard on that stuff.