| Re: celebrex/my mom's death
My condolences regarding your mother. When a tragedy such as this occurs, one always asks: Why? and How could it have been prevented?
I have mixed feelings about these lawsuits. The study that resulted in the withdrawal of Vioxx from the market consisted of about 2600 patients. Just under 2% of the patients not taking Vioxx had heart attacks, about 3.8% of those taking Vioxx had heart attacks. Of course, Merck withdrew the medicine because of the certainty of lawsuits. Yes, the risk of heart attack "nearly doubled", but the risk was still quite low. The information "almost doubled your risk of heart attack" is not enough information to make an intelligent decision regarding a treatment. Is your cup 96% full, or 4% empty? Do you count on the benefits that Cox-2 nsaids give for those 96%. I know that this is hard to hear when your mother was part of that 4%.
Apparently, there are no studies with other Cox-2 nsaids with as large a sample, or that covered as long a time period as the Vioxx study. Researchers are trying to combine several smaller studies to glean information related to the other Cox-2 inhibitors such as Celebrex. Analysis of these combined studies is the source of the possibility that Celebrex might also be a problem.
I'm not involved with the pharma industry, but I am a chemist who certainly has been involved with analysis of statistical data. And I am of the age (64) where I am thinking more about cardiovascular disease, cancer, and other degenerative health issues. Figures don't lie, but liars sure as hell figure. I am strongly in favor of the FDA changing the rules so that ALL studies are made public and that all adverse effects are reported, not just those "in support" of a treatment. But those additional data must be analyzed carefully. We have to look at population statistics.
Anything that we put in or on our bodies can have any combination of good, bad, and/or no effects. Absolutely nothing that we do is without risk of injury or even death. We are always trying to balance the good effects versus the bad. Unfortunately, we sometimes end up on the wrong side of the statistics.
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