Has anyone had a med quit working? - Depression Message Board

rainbowlight · 04-02-2002, 03:31 PM

Has anyone ever had a med quit working once it built up in your system? I had great results with Seroquel for anxiety for a couple of weeks, then it stopped working on the anxiety and just left me flat/depressed/tired. Does anyone have any idea why this happens or how to fix it? It sure is frustrating!

Dolphin · 04-02-2002, 05:18 PM

Hi rainbow. I can pitch in a couple of things that have happened to me. They take place roughly in the early 1990's or so. I took Zoloft (50mgs) for 5 years. It worked great for me till shortly before that. Then depression was back in full swing. I have tried about 18-20 AD's through the years and nothing works. Of course on some I had to quit taking because of side effects.

And years later I tried Zoloft again and I increased the dosage up to 200mgs gradually, but it didn't work, no change! Back then I used to take Buspar for anxiety, and it worked great. I remember years later I tried it again, and to my amazement, it did absolutely nothing. I even increased the dosage. Nope! No go!

I think it has to be your body chemistry that can change after years and what used to work then, doesn't now. That is just my case though. By the way, I am now taking Clonazepam (1mg) of an evening to help me sleep. Yes, it does work fine for me. I don't know how long I will stay on it. Take care. Kevin

imamom · 04-02-2002, 08:16 PM

Hi Rainbow. That happened to me with lithium. I was taking it for about 3 years when whammo...deep, deep depression hit and I went off the meds completely. When I started up the lithium again, I couldn't even keep it in....something in my body was telling me "no way"...so I'm on depakote (for now).

Hugs, Mom

kristis2 · 04-03-2002, 01:55 PM

Maybe all you need is a dose increase?! Ask your Dr about that before you try and switch! I was on paxil for 4 years and it stopped working,but I can't see a med stopping that soon,in my non-medical opinion it just needs to be increased! take care!

LMDG24 · 04-03-2002, 07:45 PM

Thats a typical reaction of any med from the class of seroquel. Seroquel is mostly used as an anti-psychotic, but it can be used for anxiety or as an anti-maniac agent. However you'll get used to it and the effect will be lost. Maybe its time to change meds... there are many others out there.