Has anyone noticed a problem with your menstrual cycle while taking Wellbutrin? I have taken the drug on and off for a couple years now and have not noticed a problem. I am on the nuvaring and very regular. I just recently started taking Wellbutrin again and started my period 5 days early while my ring was still in. On top of that I have been cramping for 4 days straight so far. I just read that menstrual complaints is one of the possible side effects. Seems strange that I would have a side effect now that I never had before.