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Old 02-01-2008, 03:04 PM   #1
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Non-responsive depression

I was diagnosed with clinical depression in 1994 and since then have been on many medications. This time, however, I am not responding as well to the medications as I'd like. I still force myself to get up and do my daily routine but it's with great effort. On days I do have off - I just want to sleep - finding that everyday life feels like a void to me - not feeling enjoyment or excitement for anything. My doctor just put me on Cymbalta with Wellbutrin but I'm wondering if anyone knows of another drug that's been known to kick stubborn depressions? For example, my doctor tried me on Risperdal a year a half ago and I had amazing results. The drugs I've been on are Effexor, Prozac, Desiprimine, Lexapro. Does anyone have any words of advice?

 
Old 02-01-2008, 03:22 PM   #2
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Re: Non-responsive depression

The MAOI class is known as breakthrough depression meds but there are a lot of food and drug interactions that tend to keep most people away.

take care
trg247
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Old 02-01-2008, 07:22 PM   #3
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Re: Non-responsive depression

Hi.....

You've been given good advise.

CBT is a very good tool.

Can I ask why you went off the Risperdal? Dreaded weight gain, by any chance?

Is your depression circumstantial?

Just thinking out loud....

Lil

 
Old 02-02-2008, 07:19 AM   #4
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Re: Non-responsive depression

What is CBT? Never heard of it before. I'm willing to try anything!!! Thanks for the feedback.

 
Old 02-02-2008, 07:47 AM   #5
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Re: Non-responsive depression

Cognitive Behavioral Therapy
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Major Depressive Disorder With Psychotic Features
Post Traumatic Stress Disorder
Borderline Personality Disorder
Generalized Anxiety Disorder

Current Meds
Pristiq
Cymbalta
Seroquel
Temazapam

 
Old 05-28-2008, 03:56 PM   #6
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Re: Non-responsive depression

I know what you mean about the NON-RESPONSIVE depression. It seems like I've done all I've been told and it doesn't get any better....good luck finding something...

 
Old 05-28-2008, 04:15 PM   #7
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Re: Non-responsive depression

I have been on Risperdal and Paroxitine for a few years. The combination works great however it has caused me to gain 100 lbs!!! I don't want to put my family through any grief so I stay on my meds but I wish there was another alternative. I still suffer from boredom, no passion for anything, however I do still enjoy things. I'm tired of not feeling my real emotions and fear that I will continue to just go through the motions every day. One good thing is that I never feel upset or extremly down anymore. May I ask what symptoms you were having when he tried you on Risperdal.

 
Old 05-28-2008, 07:15 PM   #8
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Re: Non-responsive depression

Nardil or Parnate are considered "drugs of last resort" for resistant depression.

You can combine these MAOI's with a TCA such as nortriptyline for the most powerful combo out. Ask your psychiatrist aabout it.

 
Old 05-29-2008, 12:06 PM   #9
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Re: Non-responsive depression

Lots of people are doing well with cognitive behavioral therapy. This has been a breakthrough for me. Just be patient.

 
Old 07-16-2008, 11:03 AM   #10
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Re: Non-responsive depression

I was initially put on SSRIsfor Anxiety/Depression , but the effect was minimal, if anything. The best SSRI was Cymbalta, but it did not do so much, and when I switched to Welbutrin, I felt nothing. My doctor then switched me over to Ensam - a MAOI, again with minimal effects at numerous dosages. Right now I am on Parnate - by far the most effective drug that I have used in my year-plus since being on medication. It does not even compare to the other medications.

I am also going to CBT and I must say that it is the most important part of the healing process.

Good Luck.

 
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