Cymbalta causes my thinking to become very suspicious, as in slightly paranoid thoughts. I also go into a withdrawal like state prior to the next regular dose scheduled time. The only thing it does seem to help with is pain, but it causes so much mental anguish I would never ever take it again. Withdrawal from it was a nightmare - put me in a psych hospital. They did not recognize it as withdrawal and diagnosed it a psychosis - said I was delusional because I was insisting that no lights should be turned on (massive migraine), needed low noise level, I was burning up drenched in sweat, trembling, pacing, it was HORRIBLE. No one recognized it and it was all blamed on a psych condition. It is scary these doctors playing with people's minds with some of these drugs. There is not enough emphasis on evaluating the other 'side effects' of these medications. I learned what akasthesia was the hard way. Effexor is much worse than Cymbalta - these are SNRI drugs, the SSRI drugs like Prozac effect me in a similar way but not nearly as bad. Prozac has a bad history for alot of people.